Anti-α-actinin and anti-C1q antibodies: new markers of lupus nephritis

被引：1
|
作者：
Guerrier, T. [1 ]
Jousse, S. [2 ]
Dueymes, M. [1 ]
Youinou, P. [1 ]
Renaudineau, Y. [1 ]
机构：
[1] CHU Brest, Immunol Lab, F-29606 Brest, France
[2] CHU Brest, Serv Rhumatol, F-29609 Brest, France
来源：
IMMUNO-ANALYSE & BIOLOGIE SPECIALISEE | 2007年 / 22卷 / 03期
关键词：
Systemic lupus erythematosus; Nephritis; Autoantibody; alpha-actinin; C1q;
D O I：
10.1016/j.immbio.2007.02.004
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Systemic lupus erythematosus is an autoimmune disease of which glomerulonephritis (GN) is the most frequent and serious complication. Biological diagnosis of this disease relies on antinuclear antibodies (ANA) screening, and identification of their targets. These include insoluble nuclear antigens (Ags) such as anti-DNA and soluble nuclear Ags (SSA/Ro, SSB/La, Sm, RNP). However, some of them are poorly associated with the evolution of the disease. Recent characterization of Abs in GN, resulted in the development of more reliable tests. (C) 2007 Elsevier Masson SAS. Tous droits reserves.
引用
收藏
页码：195 / 201
页数：7
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