Breast Radiotherapy: Less is More?

被引：25
作者：
Coles, C. E. [1 ]
Brunt, A. M. [2 ]
Wheatley, D. [3 ]
Mukesh, M. B. [1 ]
Yarnold, J. R. [4 ,5 ]
机构：
[1] Cambridge Univ Hosp NHS Fdn Trust, Cambridge CB2 0QQ, England
[2] Univ Hosp N Staffordshire NHS Trust, Stoke On Trent, Staffs, England
[3] Royal Cornwall Hosp NHS Trust, Truro, England
[4] Royal Marsden NHS Fdn Trust, Sutton, Surrey, England
[5] Inst Canc Res, Sutton, Surrey, England
来源：
CLINICAL ONCOLOGY | 2013年 / 25卷 / 02期
基金：
英国医学研究理事会;
关键词：
Breast cancer; clinical trials; radiotherapy; TARGETED INTRAOPERATIVE RADIOTHERAPY; CONSERVING THERAPY; WHOLE-BREAST; HYPOFRACTIONATED RADIOTHERAPY; UK STANDARDIZATION; RADIATION-THERAPY; SURGICAL CLIPS; DOSE-RESPONSE; NORMAL TISSUE; CANCER;
D O I：
10.1016/j.clon.2012.10.013
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A 3 week schedule of whole breast radiotherapy is firmly established in the UK and is becoming more accepted internationally, especially as accelerated partial breast radiotherapy regimens become more common. It seems that a 3 week schedule is unlikely to be the lower limit of whole breast hypofractionation and the partial breast may even be adequately treated with just a single treatment. It is, however, essential that these hypotheses are rigorously tested within well-designed trials to ensure the highest quality of radiotherapy. This overview will address the rationale for hypofractionation in breast cancer, discuss past trials and outline the design of current studies. (c) 2012 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：127 / 134
页数：8
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