Molecular damage in aging

被引：91

作者：

Gladyshev, Vadim N. ^{[1
,2
]}

Kritchevsky, Stephen B. ^{[3
]}

Clarke, Steven G. ^{[4
,5
]}

Cuervo, Ana Maria ^{[6
,7
]}

Fiehn, Oliver ^{[8
]}

de Magalhaes, Joao Pedro ^{[9
]}

Mau, Theresa ^{[10
]}

Maes, Michal ^{[11
]}

Moritz, Robert L. ^{[11
]}

Niedernhofer, Laura J. ^{[12
]}

Van Schaftingen, Emile ^{[13
,14
]}

Tranah, Gregory J. ^{[10
]}

Walsh, Kenneth ^{[15
]}

Yura, Yoshimitsu ^{[15
]}

Zhang, Bohan ^{[1
,2
]}

Cummings, Steven R. ^{[10
]}

机构：

[1] Brigham & Womens Hosp, Dept Med, Div Genet, 75 Francis St, Boston, MA 02115 USA

[2] Harvard Med Sch, Boston, MA 02115 USA

[3] Wake Forest Sch Med, Sect Gerontol & Geriatr Med, Dept Internal Med, Winston Salem, NC 27101 USA

[4] Univ Calif Los Angeles, Dept Chem & Biochem, 405 Hilgard Ave, Los Angeles, CA 90024 USA

[5] Univ Calif Los Angeles, Mol Biol Inst, Los Angeles, CA USA

[6] Albert Einstein Coll Med, Dept Dev & Mol Biol, New York, NY USA

[7] Albert Einstein Coll Med, Inst Aging Studies, New York, NY USA

[8] Univ Calif Davis, West Coast Metabol Ctr, Davis, CA 95616 USA

[9] Univ Liverpool, Inst Ageing & Chron Dis, Integrat Genom Ageing Grp, Liverpool, Merseyside, England

[10] Calif Pacific Med Ctr, San Francisco Coordinating Ctr, Res Inst, San Francisco, CA 94107 USA

[11] Inst Syst Biol, Seattle, WA USA

[12] Univ Minnesota, Dept Biochem Mol Biol & Biophys, Inst Biol Aging & Metab, Med Sch, Minneapolis, MN USA

[13] Catholic Univ Louvain, De Duve Inst, Brussels, Belgium

[14] Catholic Univ Louvain, Walloon Excellence Life Sci & Biotechnol WELBIO, Brussels, Belgium

[15] Univ Virginia, Sch Med, Robert M Berne Cardiovasc Res Ctr, Hematovasc Biol Ctr, Charlottesville, VA 22908 USA

来源：

NATURE AGING | 2021年 / 1卷 / 12期

基金：

美国国家卫生研究院;

关键词：

FREE-RADICAL THEORY; DNA-DAMAGE; MUTATIONAL SIGNATURES; ENZYME PROMISCUITY; LIFE-SPAN; AGE; REPAIR; ACCUMULATION; METHYLATION; SENESCENCE;

D O I：

10.1038/s43587-021-00150-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In this Review, the authors discuss the concept of molecular damage in aging, from theoretical models to experimental approaches and how to test interventions targeting aging that reduce its burden. Cellular metabolism and environmental interactions generate molecular damage affecting all levels of biological organization. Accumulation of this damage over time is thought to have a central role in the aging process. Insufficient attention has been paid to the role of molecular damage in aging-related phenotypes, particularly in humans, in part because of the difficulty in measuring its various forms. Recently, omics approaches have been developed that begin to address this challenge, because they can assess a sizable proportion of age-related damage at the level of small molecules, proteins, RNA, DNA, organelles and cells. This Review describes the concept of molecular damage in aging and discusses its diverse aspects from theoretical models to experimental approaches. Measurement of multiple types of damage enables studies of the role of damage in aging and lays a foundation for testing interventions that reduce the burden of molecular damage, thereby targeting aging.

引用

页码：1096 / 1106

页数：11

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