The Role of Natural Killer Cells in Alzheimer's Disease

被引：38

作者：

Jadidi-Niaragh, F. ^{[1
]}

Shegarfi, H. ^{[2
]}

Naddafi, F. ^{[3
]}

Mirshafiey, A. ^{[1
]}

机构：

[1] Univ Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Tehran 14155, Iran

[2] Univ Oslo, Inst Basic Med Sci, Dept Anat, Oslo, Norway

[3] Univ Tehran, Dept Sci, Tehran, Iran

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 2012年 / 76卷 / 05期

关键词：

EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; MULTIPLE-SCLEROSIS PATIENTS; CENTRAL-NERVOUS-SYSTEM; PROTEIN-KINASE-C; NK CELLS; IFN-GAMMA; EFFECTOR-CELLS; BONE-MARROW; T-CELLS; DEMENTIA;

D O I：

10.1111/j.1365-3083.2012.02769.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Alzheimers disease (AD) is a progressive neurodegenerative disorder characterized by cognitive dysfunction and selective neuronal death in the brain. The aetiology of AD is not clear but environmental factors and heritable predisposition may play a role in the disease emergence. It has also been suggested that neuralimmune interaction has a role in disease appearance. However, the underlying mechanisms are still unknown. Natural killer (NK) cells play an important role in the host defence, which is related to their ability to secrete a variety of cytokines and chemokines, as well as killing infected host cells. Moreover, there is some evidence that imply the involvement of NK cells in immunopathogenesis of AD. In this review, we have attempted to clarify the role of NK cells in the immunopathogenesis of AD.

引用

页码：451 / 456

页数：6

共 65 条

[1] Role of Protein Kinase C in TBT-Induced Inhibition of Lytic Function and MAPK Activation in Human Natural Killer Cells [J].

Abraha, Abraham B. ;

Rana, Krupa ;

Whalen, Margaret M. .

ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 2010, 59 (04) :661-669

[2] Alzheimer's disease: a review of the disease, its epidemiology and economic impact [J].

Alloul, K ;

Sauriol, L ;

Kennedy, W ;

Laurier, C ;

Tessier, G ;

Novosel, S ;

Contandriopoulos, A .

ARCHIVES OF GERONTOLOGY AND GERIATRICS, 1998, 27 (03) :189-221

[3]

[Anonymous], 2011, SCI TRANSL MED

[4] REDUCED NATURAL-KILLER-CELL ACTIVITY IN PATIENTS WITH DEMENTIA OF THE ALZHEIMER TYPE [J].

ARAGA, S ;

KAGIMOTO, H ;

FUNAMOTO, K ;

TAKAHASHI, K .

ACTA NEUROLOGICA SCANDINAVICA, 1991, 84 (03) :259-263

[5] Natural killer cell-mediated lysis of dorsal root ganglia neurons via RAE1/NKG2D interactions [J].

Backström, E ;

Chambers, BJ ;

Ho, EL ;

Naidenko, OV ;

Mariotti, R ;

Fremont, DH ;

Yokoyama, WM ;

Kristensson, K ;

Ljunggren, HG .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2003, 33 (01) :92-100

[6] Alzheimer's disease [J].

Ballard, Clive ;

Gauthier, Serge ;

Corbett, Anne ;

Brayne, Carol ;

Aarsland, Dag ;

Jones, Emma .

LANCET, 2011, 377 (9770) :1019-1031

[7] CD4 expression on activated NK cells: Ligation of CD4 induces cytokine expression and cell migration [J].

Bernstein, Helene B. ;

Plasterer, Mary C. ;

Schiff, Sherrie E. ;

Kitchen, Christina M. R. ;

Kitchen, Scott ;

Zack, Jerome A. .

JOURNAL OF IMMUNOLOGY, 2006, 177 (06) :3669-3676

[8] Regulatory CD56bright natural killer cells mediate immunomodulatory effects of IL-2Rα-targeted therapy (daclizumab) in multiple sclerosis [J].

Bielekova, B ;

Catalfamo, M ;

Reichert-Scrivner, S ;

Packer, A ;

Cerna, M ;

Waldmann, TA ;

McFarland, H ;

Henkart, PA ;

Martin, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (15) :5941-5946

[9] TWIN STUDIES OF ALZHEIMERS-DISEASE - AN APPROACH TO ETIOLOGY AND PREVENTION [J].

BREITNER, JCS ;

MURPHY, EA ;

FOLSTEIN, MF ;

MAGRUDERHABIB, K .

NEUROBIOLOGY OF AGING, 1990, 11 (06) :641-648

[10] Early risk assessment for Alzheimer's disease [J].

Carrillo, Maria C. ;

Blackwell, Andrew ;

Hampel, Harald ;

Lindborg, Johan ;

Sperling, Reisa ;

Schenk, Dale ;

Sevigny, Jeffrey J. ;

Ferris, Steven ;

Bennett, David A. ;

Craft, Suzanne ;

Hsu, Timothy ;

Klunk, William .

ALZHEIMERS & DEMENTIA, 2009, 5 (02) :182-196

← 1 2 3 4 5 6 7 →