Exposure to indoor allergens in day-care facilities: Results from 2 North Carolina counties

被引:52
作者
Arbes, SJ [1 ]
Sever, M [1 ]
Mehta, J [1 ]
Collette, N [1 ]
Thomas, B [1 ]
Zeldin, DC [1 ]
机构
[1] NIEHS, NIH, Div Intramural Res, Res Triangle Pk, NC 27709 USA
基金
美国国家卫生研究院;
关键词
alternaria species; Alt a 1; Bla g 1; Can f 1; cat allergen; child day-care centers; cockroach allergen; day care; Der f 1; Der p 1; dog allergen; dust mite allergen; Fel d 1; indoor allergens; mouse allergen; Mus m 1;
D O I
10.1016/j.jaci.2005.04.022
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Background: With 63% of US children under 5 years of age in regular child care, day-care facilities could be an important source of exposure to indoor allergens. Objective: This study examined levels of 7 indoor allergens in 89 day-care facilities in 2 North Carolina counties. Methods: At each facility, a questionnaire was administered, observations were made, and vacuumed dust samples were collected from carpeted and noncarpeted areas of one room. Allergen concentrations were measured with antibody-based ELISAs. Results: Each allergen was detected in a majority of facilities (52% to 100%). Geometric mean concentrations were 5.19 mu g/g for Alternaria alternata, 2.06 mu g/g for Can f 1, 1.43 mu g/g for Fel d 1, 0.21 U/g for Bla g 1, 0.20 mu g/g for Der p 1, 0.10 mu g/g for Der f 1, and 0.01 mu g/g for Mus m 1. Concentrations for 5 of the 7 allergens were not statistically different from concentrations found in southern US homes sampled in the National Survey of Lead and Allergens in Housing. In rooms with carpet and hard-surfaced flooring, levels of A alternata, Can f 1, Der f 1, Der p 1, and Fel d 1 were statistically higher on carpet. Conclusions: In this survey of day-care facilities in North Carolina, detectable levels of indoor allergens were commonly found. For many young children and day-care staff, day-care facilities might be a source of clinically relevant exposures to indoor allergens.
引用
收藏
页码:133 / 139
页数:7
相关论文
共 31 条
  • [11] QUANTITATIVE ASSESSMENT OF EXPOSURE TO DOG (CAN-F-1) AND CAT (FEL-D-1) ALLERGENS - RELATION TO SENSITIZATION AND ASTHMA AMONG CHILDREN LIVING IN LOS-ALAMOS, NEW-MEXICO
    INGRAM, JM
    SPORIK, R
    ROSE, G
    HONSINGER, R
    CHAPMAN, MD
    PLATTSMILLS, TAE
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1995, 96 (04) : 449 - 456
  • [12] House-dust mites and asthma. A review on house-dust mites as a domestic risk factor for mite asthma
    Korsgaard, J
    [J]. ALLERGY, 1998, 53 : 77 - 83
  • [13] MITE ALLERGEN EXPOSURE IS A RISK FOR THE INCIDENCE OF SPECIFIC SENSITIZATION
    KUEHR, J
    FRISCHER, T
    MEINERT, R
    BARTH, R
    FORSTER, J
    SCHRAUB, S
    URBANEK, R
    KARMAUS, W
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1994, 94 (01) : 44 - 52
  • [14] HIGH MITE-ALLERGEN EXPOSURE INCREASES THE RISK OF SENSITIZATION IN ATOPIC CHILDREN AND YOUNG-ADULTS
    LAU, S
    FALKENHORST, G
    WEBER, A
    WERTHMANN, I
    LIND, P
    BUETTNERGOETZ, P
    WAHN, U
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1989, 84 (05) : 718 - 725
  • [15] Prenatal exposure, maternal sensitization,, and sensitization in utero to indoor allergens in an inner-city cohort
    Miller, RL
    Chew, GL
    Bell, CA
    Biedermann, SA
    Aggarwal, M
    Kinney, PL
    Tsai, WY
    Whyatt, RM
    Perera, FP
    Ford, JG
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2001, 164 (06) : 995 - 1001
  • [16] MITE (DER-P-I, DER-F-I), CAT (FEL-D-I) AND DOG (CAN-F-I) ALLERGENS IN DUST FROM SWEDISH DAY-CARE-CENTERS
    MUNIR, AKM
    EINARSSON, R
    DREBORG, SKG
    [J]. CLINICAL AND EXPERIMENTAL ALLERGY, 1995, 25 (02) : 119 - 126
  • [17] Phipatanakul W, 2000, J ALLERGY CLIN IMMUN, V106, P1075, DOI 10.1067/mai.2000.110795
  • [18] PLATTSMILLS TA, 1997, J ALLERGY CLIN IMM S, V100, P2
  • [19] EPIDEMIOLOGY OF THE RELATIONSHIP BETWEEN EXPOSURE TO INDOOR ALLERGENS AND ASTHMA
    PLATTSMILLS, TAE
    WARD, GW
    SPORIK, R
    GELBER, LE
    CHAPMAN, MD
    HEYMANN, PW
    [J]. INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1991, 94 (1-4): : 339 - 345
  • [20] SEASONAL-VARIATION IN DUST MITE AND GRASS-POLLEN ALLERGENS IN DUST FROM THE HOUSES OF PATIENTS WITH ASTHMA
    PLATTSMILLS, TAE
    HAYDEN, ML
    CHAPMAN, MD
    WILKINS, SR
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1987, 79 (05) : 781 - 791