An Early Investigation of Ytterbium Nanocolloids for Selective and Quantitative "Multicolor" Spectral CT Imaging

被引：106

作者：

Pan, Dipanjan ^{[1
,2
]}

Schirra, Carsten O. ^{[3
]}

Senpan, Angana ^{[1
,2
]}

Schmieder, Anne H. ^{[1
,2
]}

Stacy, Allen J. ^{[1
,2
]}

Roessl, Ewald ^{[4
]}

Thran, Axel ^{[4
]}

Wickline, Samuel A. ^{[1
,2
]}

Proska, Roland ^{[4
]}

Lanza, Gregory M. ^{[1
,2
]}

机构：

[1] Washington Univ, Sch Med, C TRAIN, St Louis, MO 63108 USA

[2] Washington Univ, Sch Med, Div Cardiol, St Louis, MO 63108 USA

[3] Philips Res N Amer, Briarcliff Manor, NY 10510 USA

[4] Philips Res Europe Hamburg, D-22335 Hamburg, Germany

来源：

ACS NANO | 2012年 / 6卷 / 04期

关键词：

ytterbium; nanoparticle; spectral CT imaging; contrast agent; multicolor imaging; thrombus; CORONARY-ARTERY CALCIFICATION; COMPUTED-TOMOGRAPHY; PLAQUE MORPHOLOGY; DTPA;

D O I：

10.1021/nn300392x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a novel molecular imaging agent based on ytterbium designed for use with spectral "multicolor" computed tomography (CT). Spectral CT or multicolored CT provides all of the benefits of traditional CT, such as rapid tomographic X-ray imaging, but in addition, it simultaneously discriminates metal-rich contrast agents based on the element's unique X-ray K-edge energy signature. Our synthetic approach involved the use of organically soluble Yb(III) complex to produce nanocolloids of Yb of noncrystalline nature incorporating a high density of Yb (>500K/nanoparticle) into a stable metal particle. The resultant particles are constrained to vasculature (similar to 200 nm) and are highly selective for binding fibrin in the ruptured atherosclerotic plaque. Nanoparticles exhibited excellent signal sensitivity, and the spectral CT technique uniquely discriminates the K-edge signal (60 keV) of Yb from calcium (bones). Bioelimination and preliminary biodistribution reflected the overall safety and defined clearance of these particles in a rodent model.

引用

页码：3364 / 3370

页数：7

共 18 条

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[2]

Benson RL, 1926, ARCH PATHOL LAB MED, V2, P876

[3] PLAQUE FISSURES IN HUMAN CORONARY THROMBOSIS [J].