Physicochemical Properties and Biocompatibility of White Dextrin Modified Injectable Calcium-Magnesium Phosphate Cement

被引:4
作者
Chen, Fangping [1 ,2 ]
Liu, Changsheng [1 ,2 ]
Wei, Jie [2 ,3 ]
Chen, Xiaolong [3 ]
机构
[1] E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China
[2] E China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China
[3] E China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Minist Educ, Shanghai 200237, Peoples R China
基金
上海市自然科学基金; 美国国家科学基金会;
关键词
BONE REGENERATION; IN-VITRO; RHEOLOGICAL PROPERTIES; SURFACE; DIFFERENTIATION; PROLIFERATION; BIOACTIVITY; ICODEXTRIN; AGENTS;
D O I
10.1111/j.1744-7402.2011.02705.x
中图分类号
TQ174 [陶瓷工业]; TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
The objective of this study was to develop anti-washout and fast-setting calciummagnesium phosphate cement (as-CMP) by introducing white dextrin (WD) and magnesium phosphate cement (MPC) to CPC. The results showed that WD imparted anti-washout to the as-CMP paste, whereas MPC simultaneously improved the paste anti-washout and fast-setting. The synergistic effect of MPC and WD obviously shortened the setting time of as-CMP. The WD did not affect the phase evolution and microstructure of the paste. Furthermore, all samples were biocompatible and as-CMP exhibited the best cell metabolic activity, cell attachment, and proliferation, which would provide basic data for the clinical application.
引用
收藏
页码:979 / 990
页数:12
相关论文
共 45 条
[11]   Effects of α-TCP and TetCP on MC3T3-E1 proliferation, differentiation and mineralization [J].
Ehara, A ;
Ogata, K ;
Imazato, S ;
Ebisu, S ;
Nakano, T ;
Umakoshi, Y .
BIOMATERIALS, 2003, 24 (05) :831-836
[12]   Icodextrin - A review of its use in peritoneal dialysis [J].
Frampton, JE ;
Plosker, GL .
DRUGS, 2003, 63 (19) :2079-2105
[13]  
HAlkhraisat M., 2010, ACTA BIOMATER, V6, P257
[14]   Third-generation biomedical materials [J].
Hench, LL ;
Polak, JM .
SCIENCE, 2002, 295 (5557) :1014-+
[15]   A pilot study of adjuvant intraperitoneal 5-fluorouracil using 4% icodextrin as a novel carrier solution [J].
Hosie, KB ;
Kerr, DJ ;
Gilbert, JA ;
Downes, M ;
Lakin, G ;
Pemberton, G ;
Timms, K ;
Young, A ;
Stanley, A .
EUROPEAN JOURNAL OF SURGICAL ONCOLOGY, 2003, 29 (03) :254-260
[16]  
Hreczuk H. D., 2001, INT J PHARMACEUT, V230, P57
[17]   NON-DECAY TYPE FAST-SETTING CALCIUM-PHOSPHATE CEMENT - COMPOSITE WITH SODIUM ALGINATE [J].
ISHIKAWA, K ;
MIYAMOTO, Y ;
KON, M ;
NAGAYAMA, M ;
ASAOKA, K .
BIOMATERIALS, 1995, 16 (07) :527-532
[18]   Development of magnesium calcium phosphate biocement for bone regeneration [J].
Jia, Junfeng ;
Zhou, Huanjun ;
Wei, Jie ;
Jiang, Xin ;
Hua, Hong ;
Chen, Fangping ;
Wei, Shicheng ;
Shin, Jung-Woog ;
Liu, Changsheng .
JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2010, 7 (49) :1171-1180
[19]   Viscosity-enhancing admixtures for cement-based materials - An overview [J].
Khayat, KH .
CEMENT & CONCRETE COMPOSITES, 1998, 20 (2-3) :171-188
[20]   Effect of rapidly resorbable calcium phosphates and a calcium phosphate bone cement on the expression of bone-related genes and proteins in vitro [J].
Knabe, C ;
Berger, G ;
Gildenhaar, R ;
Meyer, J ;
Howlett, CR ;
Markovic, B ;
Zreiqat, H .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2004, 69A (01) :145-154