Synthesis and Pharmacological Evaluation of Some New Chromeno[3,4-c]pyrrole-3,4-dione-based N-Heterocycles as Antimicrobial Agents

The reaction of 2-oxo-2H-chromene-3-carboxamide (1) with carbon disulfide afforded 1-mercaptopyrrolo[3,4-c]chromene-3,4-dione (3). The latter compound was utilized as versatile building block for new azole systems via incorporating in a series of manipulations including cyclocondensation reactions. The structure of the newly synthesized compounds has been confirmed by IR, H-1 NMR, C-13 NMR, mass spectral, and elemental analysis. Furthermore, some selected compounds were screened in vitro for their antimicrobial activities. The results declared that most of the synthesized compounds have high antimicrobial activity.