Synthetic cannabinoids: Analysis and metabolites

被引：108

作者：

ElSohly, Mahmoud A. ^{[1
,2
,3
]}

Gul, Waseem ^{[1
,2
]}

Wanas, Amira S. ^{[2
,4
]}

Radwan, Mohamed M. ^{[2
,5
]}

机构：

[1] ElSohly Labs Inc, Oxford, MS 38655 USA

[2] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA

[3] Univ Mississippi, Sch Pharm, Dept Pharmaceut, University, MS 38677 USA

[4] Menia Univ, Fac Pharm, Dept Pharmacognosy, Al Minya, Egypt

[5] Univ Alexandria, Fac Pharm, Dept Pharmacognosy, Alexandria, Egypt

来源：

LIFE SCIENCES | 2014年 / 97卷 / 01期

关键词：

Synthetic cannabinoids; Analysis; Herbal products; Metabolites; CHROMATOGRAPHY-MASS SPECTROMETRY; DESIGNER DRUGS; HERBAL BLENDS; IN-VITRO; LC-MS/MS; IDENTIFICATION; JWH-018; QUANTIFICATION; VALIDATION; TOF;

D O I：

10.1016/j.lfs.2013.12.212

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cannabimimetics (commonly referred to as synthetic cannabinoids), a group of compounds encompassing a wide range of chemical structures, have been developed by scientists with the hope of achieving selectivity toward one or the other of the cannabinoid receptors CB1 and CB2. The goal was to have compounds that could possess high therapeutic activity without many side effects. However, underground laboratories have used the information generated by the scientific community to develop these compounds for illicit use as marijuana substitutes. This chapter reviews the different classes of these "synthetic cannabinoids" with particular emphasis on the methods used for their identification in the herbal products with which they are mixed and identification of their metabolites in biological specimens. (C) 2014 Published by Elsevier Inc.

引用

页码：78 / 90

页数：13

共 47 条

[31] Rapid identification of synthetic cannabinoids in herbal samples via direct analysis in real time mass spectrometry
Musah, Rabi A.
Domin, Marek A.
Walling, Maureen A.
Shepard, Jason R. E.
[J]. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2012, 26 (09) : 1109 - 1114
[32] Detection of synthetic cannabinoids in herbal incense products
Penn, Hannah J.
Langman, Loralie J.
Unold, David
Shields, James
Nichols, James H.
[J]. CLINICAL BIOCHEMISTRY, 2011, 44 (13) : 1163 - 1165
[33] Peters F.T., 2009, TOXICHEM KRIMTECH, V76, P185
[34] Validation of new methods
Peters, Frank T.
Drummer, Olaf H.
Musshoff, Frank
[J]. FORENSIC SCIENCE INTERNATIONAL, 2007, 165 (2-3) : 216 - 224
[35] Bioanalytical method validation and its implications for forensic and clinical toxicology - A review
Peters, FT
Maurer, HH
[J]. ACCREDITATION AND QUALITY ASSURANCE, 2002, 7 (11) : 441 - 449
[36] Rollins C, 2013, 245 ACS NAT M EXP NE
[37] Simultaneous analysis of several synthetic cannabinoids, THC, CBD and CBN, in hair by ultra-high performance liquid chromatography tandem mass spectrometry. Method validation and application to real samples
Salomone, A.
Gerace, E.
D'Urso, F.
Di Corcia, D.
Vincenti, M.
[J]. JOURNAL OF MASS SPECTROMETRY, 2012, 47 (05): : 604 - 610
[38] A Major Glucuronidated Metabolite of JWH-018 Is a Neutral Antagonist at CB1 Receptors
Seely, Kathryn A.
Brents, Lisa K.
Radominska-Pandya, Anna
Endres, Gregory W.
Keyes, Gregory S.
Moran, Jeffery H.
Prather, Paul L.
[J]. CHEMICAL RESEARCH IN TOXICOLOGY, 2012, 25 (04) : 825 - 827
[39] Application of mass spectrometry to the structural identification of the metabolites of the synthetic cannabinoid JWH-018 and the determination of them in human urine
Sobolevskii, T. G.
Prasolov, I. S.
Rodchenkov, G. M.
[J]. JOURNAL OF ANALYTICAL CHEMISTRY, 2011, 66 (13) : 1314 - 1323
[40] Detection of JWH-018 metabolites in smoking mixture post-administration urine
Sobolevsky, Tim
Prasolov, Ilya
Rodchenkov, Grigory
[J]. FORENSIC SCIENCE INTERNATIONAL, 2010, 200 (1-3) : 141 - 147

← 1 2 3 4 5 →