Synthetic cannabinoids: Analysis and metabolites

被引：111

作者：

ElSohly, Mahmoud A. ^{[1
,2
,3
]}

Gul, Waseem ^{[1
,2
]}

Wanas, Amira S. ^{[2
,4
]}

Radwan, Mohamed M. ^{[2
,5
]}

机构：

[1] ElSohly Labs Inc, Oxford, MS 38655 USA

[2] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA

[3] Univ Mississippi, Sch Pharm, Dept Pharmaceut, University, MS 38677 USA

[4] Menia Univ, Fac Pharm, Dept Pharmacognosy, Al Minya, Egypt

[5] Univ Alexandria, Fac Pharm, Dept Pharmacognosy, Alexandria, Egypt

来源：

LIFE SCIENCES | 2014年 / 97卷 / 01期

关键词：

Synthetic cannabinoids; Analysis; Herbal products; Metabolites; CHROMATOGRAPHY-MASS SPECTROMETRY; DESIGNER DRUGS; HERBAL BLENDS; IN-VITRO; LC-MS/MS; IDENTIFICATION; JWH-018; QUANTIFICATION; VALIDATION; TOF;

D O I：

10.1016/j.lfs.2013.12.212

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cannabimimetics (commonly referred to as synthetic cannabinoids), a group of compounds encompassing a wide range of chemical structures, have been developed by scientists with the hope of achieving selectivity toward one or the other of the cannabinoid receptors CB1 and CB2. The goal was to have compounds that could possess high therapeutic activity without many side effects. However, underground laboratories have used the information generated by the scientific community to develop these compounds for illicit use as marijuana substitutes. This chapter reviews the different classes of these "synthetic cannabinoids" with particular emphasis on the methods used for their identification in the herbal products with which they are mixed and identification of their metabolites in biological specimens. (C) 2014 Published by Elsevier Inc.

引用

页码：78 / 90

页数：13

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