Laparoscopic anti-reflux surgery to treat proton pump inhibitor-resistant non-erosive reflux disease

被引：2

作者：

Nomura, Tsutomu ^{[1
]}

Iwakiri, Katsuhiko ^{[2
]}

Matsutani, Takeshi ^{[1
]}

Hagiwara, Nobutoshi ^{[1
]}

Makino, Hiroshi ^{[3
]}

Maruyama, Hiroshi ^{[3
]}

Fujita, Itsuro ^{[1
]}

Nakamura, Yoshiharu ^{[1
]}

Kawami, Noriyuki ^{[2
]}

Miyashita, Masao ^{[1
]}

Uchida, Eiji ^{[1
]}

机构：

[1] Nippon Med Sch, Div Digest Surg, Dept Med, Bunkyo Ku, Tokyo 113, Japan

[2] Nippon Med Sch, Div Gastroenterol, Dept Med, Tokyo 113, Japan

[3] Nippon Med Sch, Dept Surg, Tama Nagayama Hosp, Tokyo 113, Japan

来源：

ESOPHAGUS | 2013年 / 10卷 / 03期

关键词：

pH; Gastric acid reflux; Fundoplication; Laparoscopy; MULTICHANNEL INTRALUMINAL IMPEDANCE; GASTROESOPHAGEAL-REFLUX; SYMPTOM INDEX; FUNDOPLICATION; ACID;

D O I：

10.1007/s10388-013-0360-1

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We performed surgery for proton pump inhibitor-resistant non-erosive reflux disease patients whose symptom index, confirmed by combined multichannel intraluminal impedance-pH monitoring, was positive. Laparoscopic Nissen fundoplication was performed in five patients and laparoscopic Toupet fundoplication in 3 patients. In 6 of 8 patients, non-acid or minor acid reflux caused the symptoms. Satisfaction percentages assessed 1 year postoperatively were 12.5 % (excellent) and 87.5 % (good).The number of total reflux events decreased to 28.5 +/- A 14.4 % postoperatively. The symptom index decreased from 63.8 to 20.8 %. It is controversial whether the surgery reduces weakly acidic reflux to the same degree as acid reflux. Previous reports discuss the effect of laparoscopic Nissen fundoplication on acid and weakly acidic reflux; however, the results of these studies are contradictory. In our cases, laparoscopic Toupet fundoplication as well as Nissen fundoplication improved symptoms, and reduced acid and non-acid reflux similarly. These findings strongly support the importance of surgical intervention in proton pump inhibitor-resistant non-erosive reflux disease patients.

引用

页码：157 / 160

页数：4

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