Application of Phage-Displayed Peptides in Tumor Imaging Diagnosis and Targeting Therapy

被引:24
|
作者
Li, Chunyan [1 ]
Li, Jia [1 ]
Xu, Ying [1 ]
Zhan, Ying [2 ]
Li, Yu [1 ]
Song, Tingting [1 ]
Zheng, Jiao [1 ]
Yang, Hong [1 ]
机构
[1] Air Force Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 1, 127 West ChangLe Rd, Xian 710032, Shaanxi, Peoples R China
[2] PLA, Hosp 518, Xian 710043, Shaanxi, Peoples R China
关键词
Targeting peptides; Phage display; Tumor imaging diagnosis; Tumor targeting therapy; PROSTATE-CANCER; NANOPARTICLES; ANTIGENS; PROBES; IDENTIFICATION; RECEPTORS; BIOMARKER; PROGRESS; BINDING; DESIGN;
D O I
10.1007/s10989-020-10108-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Phage display is an effective and powerful technique that provides a route to discovery unique peptides targeting to tumor cells. Specifically binding peptides are considered as the valuable target directing molecule fragments with potential efficiency to improve the current tumor clinic, and offer new approaches for tumor prevention, diagnosis and treatment. We focus on the recent advances in the isolation of tumor-targeting peptides by biopanning methods, with particular emphasis on molecular imaging, and pharmaceutical targeting therapy.
引用
收藏
页码:587 / 595
页数:9
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