3-alkylthiomethyl-1-ethylimidazolium chlorides. Correlation between critical micelle concentrations and minimum inhibitory concentrations

被引：32

作者：

Pernak, J

Skrzypczak, A

机构：

[1] Poznań Univ. of Technology, 60-965 Poznań

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1996年 / 31卷 / 11期

关键词：

3-alkylthiomethyl-1-ethylimidazolium chloride; synthesis; S(N)1 mechanism; cationic surfactant; minimum inhibitory concentration; critical micelle concentration; hydrophobicity index;

D O I：

10.1016/S0223-5234(97)89853-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

3-Alkylthiomethyl-1-ethylimidazolium chlorides were prepared in high yield via an S(N)1 reaction. The critical micelle concentration (CMC) values of studied chlorides were determined by surface tensiometry and the hydrophobicity index (HI) was calculated. The minimum inhibitory concentration (MIC) against various microorganisms such as cocci, rods, fungi and bacilli was studied. The quantitative relationship between the MIC, the CMC and the HI was calculated.

引用

页码：901 / 903

页数：3