Palladium-Catalyzed Cascade Desulfitative Arylation of Acetylinic Oximes with Sodium Arylsulfinates

被引：4

作者：

Li, Jianxiao ^{[1
]}

Cen, Liying ^{[1
]}

He, Dan ^{[1
]}

Zhou, Daohao ^{[1
]}

Huang, Songxuan ^{[1
]}

机构：

[1] South China Univ Technol, Sch Chem & Chem Engn, Key Lab Funct Mol Engn Guangdong Prov, 381 Wushan Rd, Guangzhou 510641, Guangdong, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 2022卷 / 20期

基金：

中国国家自然科学基金;

关键词：

Alkynes; Arylation; Annulation; Desulfurization; Palladium; ALKYNONE O-METHYLOXIMES; ISOXAZOLES; CYCLIZATION; RING; ALKENYLATION; HETEROCYCLES; ANNULATION; REACTIVITY;

D O I：

10.1002/ejoc.202200294

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein described a highly efficient palladium-catalyzed cascade desulfitative arylation of acetylinic oximes and sodium arylsulfinates with oxygen as the sole oxidant to access structurally diverse 4-aryl isoxazoles. This catalytic system exhibits mild conditions, broad substrate scope, and operational simplicity. Notably, other easily available aryl source substrates were perfectly tolerated in this catalytic system, thus providing a promising application in synthetic and pharmaceutical chemistry.

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页数：5

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