Prediction of Alzheimer disease in subjects with amnestic and nonamnestic MCI

被引：113

作者：

Vos, Stephanie J. B. ^{[1
]}

van Rossum, Ineke A. ^{[2
]}

Verhey, Frans ^{[1
]}

Knol, Dirk L. ^{[3
]}

Soininen, Hilkka ^{[4
,5
]}

Wahlund, Lars-Olof ^{[6
]}

Hampel, Harald ^{[7
]}

Tsolaki, Magda ^{[8
]}

Minthon, Lennart ^{[9
]}

Frisoni, Giovanni B. ^{[10
,11
]}

Froelich, Lutz ^{[12
]}

Nobili, Flavio ^{[13
]}

van der Flier, Wiesje ^{[2
]}

Blennow, Kaj ^{[14
]}

Wolz, Robin ^{[15
]}

Scheltens, Philip ^{[2
]}

Visser, Pieter Jelle ^{[1
,2
]}

机构：

[1] Maastricht Univ, Sch Mental Hlth & Neurosci, Alzheimer Ctr Limburg, Dept Psychiat & Neuropsychol, Maastricht, Netherlands

[2] Vrije Univ Amsterdam, Med Ctr, Dept Neurol, Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Med Ctr, Dept Epidemiol & Biostat, Amsterdam, Netherlands

[4] Univ Eastern Finland, Dept Neurol, Kuopio, Finland

[5] Kuopio Univ Hosp, SF-70210 Kuopio, Finland

[6] Karolinska Inst, Dept NVS, Sect Clin Geriatr, Karolinska Univ Hosp, Huddinge, Sweden

[7] Goethe Univ Frankfurt, Dept Psychiat, D-60054 Frankfurt, Germany

[8] Aristotle Univ Thessaloniki, Memory & Dementia Ctr, Dept Neurol 3, Papanicolaou Gen Hosp G, GR-54006 Thessaloniki, Greece

[9] Lund Univ, Clin Memory Res Unit, Dept Clin Sci Malmo, S-22100 Lund, Sweden

[10] IRCCS San Giovanni di Dio Fatebenefratelli, Lab Epidemiol & Neuroimaging, Brescia, Italy

[11] IRCCS San Giovanni di Dio Fatebenefratelli, Translat Res Unit, Brescia, Italy

[12] Heidelberg Univ, Dept Geriatr Psychiat, Zent Inst Seel Gesundheit, Mannheim, Germany

[13] Univ Genoa, Clin Neurophysiol Serv, Dept Neurosci Ophthalmol & Genet, I-16126 Genoa, Italy

[14] Univ Gothenburg, Sahlgrenska Univ Hosp, Clin Neurochem Lab, Molndal, Sweden

[15] Univ London Imperial Coll Sci Technol & Med, Dept Comp, London SW7 2AZ, England

来源：

NEUROLOGY | 2013年 / 80卷 / 12期

关键词：

MILD COGNITIVE IMPAIRMENT; CEREBROSPINAL-FLUID; DEMENTIA; BIOMARKERS; TAU; PROGRESSION; ATROPHY; TIME; CSF; AD;

D O I：

10.1212/WNL.0b013e318288690c

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To compare the predictive accuracy of beta-amyloid (A beta)1-42 and total tau in CSF, hippocampal volume (HCV), and APOE genotype for Alzheimer disease (AD)-type dementia in subjects with amnestic mild cognitive impairment (aMCI) and nonamnestic mild cognitive impairment (naMCI). Methods: We selected 399 subjects with aMCI and 226 subjects with naMCI from a multicenter memory clinic-based cohort. We measured CSF A beta 1-42 and tau by ELISA (n = 231), HCV on MRI (n = 388), and APOE epsilon 4 (n = 523). Follow-up was performed annually up to 5 years. Outcome measures were progression to AD-type dementia and cognitive decline. Results: At least 1 follow-up was available for 538 subjects (86%). One hundred thirty-two subjects with aMCI (38%) and 39 subjects with naMCI (20%) progressed to AD-type dementia after an average follow-up of 2.5 years. CSF A beta 1-42, tau, A beta 1-42/tau ratio, HCV, and APOE epsilon 4 predicted AD-type dementia in each MCI subgroup with the same overall diagnostic accuracy. However, CSF A beta 1-42 concentration was higher and hippocampal atrophy less severe in subjects with naMCI compared with aMCI. This reduced the sensitivity but increased the specificity of these markers for AD-type dementia in subjects with naMCI. Conclusions: AD biomarkers are useful to predict AD-type dementia in subjects with aMCI and naMCI. However, biomarkers might not be as sensitive for early diagnosis of AD in naMCI compared with aMCI. This may have implications for clinical implementation of the National Institute on Aging and Alzheimer's Association criteria. Neurology (R) 2013; 80:1124-1132

引用

页码：1124 / 1132

页数：9

共 31 条

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