Human Germ line Genetic Modification: Scientific and Bioethical Perspectives

被引：19

作者：

Smith, Kevin R. ^{[1
]}

Chan, Sarah ^{[2
]}

Harris, John ^{[2
]}

机构：

[1] Abertay Univ, Sch Contemporary Sci, Dundee DD1 1HG, Scotland

[2] Univ Manchester, Inst Sci Eth & Innovat, Manchester M13 9PL, Lancs, England

来源：

ARCHIVES OF MEDICAL RESEARCH | 2012年 / 43卷 / 07期

关键词：

Human germline; Genetic modification; Gene targeting; Gene therapy; Genetic enhancement; Genethics; ZINC-FINGER NUCLEASES; EMBRYONIC STEM-CELLS; INTRACYTOPLASMIC SPERM INJECTION; TISSUE-SPECIFIC EXPRESSION; RNA-DNA OLIGONUCLEOTIDES; HOMOLOGOUS RECOMBINATION; TRANSGENIC MICE; PRONUCLEAR MICROINJECTION; INSERTIONAL MUTAGENESIS; PRECAUTIONARY PRINCIPLE;

D O I：

10.1016/j.arcmed.2012.09.003

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The latest mammalian genetic modification technology offers efficient and reliable targeting of genomic sequences, in the guise of designer genetic recombination tools. These and other improvements in genetic engineering technology suggest that human germline genetic modification (HGGM) will become a safe and effective prospect in the relatively near future. Several substantive ethical objections have been raised against HGGM including claims of unacceptably high levels of risk, damage to the status of future persons, and violations of justice and autonomy. This paper critically reviews the latest GM science and discusses the key ethical objections to HGGM. We conclude that major benefits are likely to accrue through the use of safe and effective HGGM and that it would thus be unethical to take a precautionary stance Against HGGM. (C) 2012 IMSS. Published by Elsevier Inc.

引用

页码：491 / 513

页数：23

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