Low-dose dexamethasone suppression test in chronic fatigue syndrome and health

被引：75

作者：

Gaab, J ^{[1
]}

Hüster, D ^{[1
]}

Peisen, R ^{[1
]}

Engert, V ^{[1
]}

Schad, T ^{[1
]}

Schürmeyer, TH ^{[1
]}

Ehlert, U ^{[1
]}

机构：

[1] Univ Trier, Ctr Psychobiol & Psychosomat Res, Trier, Germany

来源：

PSYCHOSOMATIC MEDICINE | 2002年 / 64卷 / 02期

关键词：

chronic fatigue syndrome; HPA axis; salivary cortisol; dexamethasone;

D O I：

10.1097/00006842-200203000-00015

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: Subtle dysregulations of the hypothalamus-pituitary-adrenal axis in chronic fatigue syndrome have been described. The aim of this study was to examine the negative feedback regulations of the hypothalamus-pituitary-adrenal axis in chronic fatigue syndrome. Methods: In 21 patients with chronic fatigue syndrome and 21 healthy control subjects, awakening and circadian salivary free cortisol profiles were assessed over 2 consecutive days and compared with awakening and circadian salivary free cortisol profiles after administration of 0.5 mg of dexamethasone at 11:00 PM the previous day. Results: Patients with chronic fatigue syndrome had normal salivary free cortisol profiles but showed enhanced and prolonged suppression of salivary free cortisol after the administration of 0.5 mg of dexamethasone in comparison to the control subjects. Conclusions: Enhanced negative feedback of the hypothalamus-pituitary-adrenal axis could be a plausible explanation for the previously described alterations in hypothalamus-pituitary-adrenal axis functioning in chronic fatigue syndrome. Because similar changes have been described in stress-related disorders, a putative role of stress in the pathogenesis of the enhanced feedback is possible.

引用

页码：311 / 318

页数：8

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