Effectiveness of BNT162b2 vaccine to preventing COVID-19 in healthcare personnel

Objective: To assess the effectiveness of the vaccine against SARS-CoV-2 (BNT162b2) in healthcare per-sonnel of a health department. Method: Test-negative case-control study. Healthcare personnel with suspected COVID-19 and health-care personnel close contacts of COVID-19 cases were included between January 27th and June 6 th, 2021. They were PCR tested for SARS-CoV-2; those with positive PCR were considered cases and those with negative PCR were considered controls. The adjusted vaccine effectiveness (aVE) to prevent COVID-19 cases and their 95% confidence interval (95%CI) were calculated using the formula VE = (1 - odds ratio) x 100.Results: 624 healthcare personnel were included, of which 43 (6.9%) were considered cases and 581 (93.8%) controls. The aVE of the complete regimen was 96.3% (95%CI: 82.5-99.2). The aVE of the incom-plete pattern was 68.0% (95%CI: 30.0-85.4).Conclusions: The administration of the complete pattern of BNT162b2 vaccine against SARS-CoV-2 is effective for the prevention of cases of COVID-19 in healthcare personnel.(c) 2021 SESPAS. Published by Elsevier Espana, S.L.U.