Synthesis and anti-inflammatory activity evaluation of unsymmetrical selenides

被引：14
作者：
Martinez-Ramos, Federico [1 ]
Salgado-Zamora, Hector [2 ]
Elena Campos-Aldrete, Maria [2 ]
Melendez-Camargo, Estela [3 ]
Marquez-Flores, Yazmin [3 ]
Soriano-Garcia, Manuel [4 ]
机构：
[1] Escuela Nacl Ciencias Biol, Dept Quim Inorgan, Mexico City 11340, DF, Mexico
[2] Escuela Nacl Ciencias Biol, Dept Quim Organ, Mexico City 11340, DF, Mexico
[3] Escuela Nacl Ciencias Biol, Dept Farm, Mexico City 11340, DF, Mexico
[4] Univ Nacl Autonoma Mexico, Dept Bioestruct, Inst Quim, CU, Mexico City 04510, DF, Mexico
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2008年 / 43卷 / 07期
关键词：
anti-inflammatory activity; alkylselenenyl benzoic acid derivatives; granuloma bioassay;
D O I：
10.1016/j.ejmech.2007.09.029
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The alkylation reaction of 2,2'-diseleno and 4,4'-diseleno-bis(benzoic acid) derivatives in the presence of sodium borohydride and alkyl halides allowed the synthesis of various new o- and p-alkylselenenylated benzoic acid derivatives in good yields. The anti-inflammatory activity of selected selenide derivatives on granuloma induced by subcutaneous implantation of cotton pellets in Wistar rats was examined. Selenium derivatives 2a, 2c and 2e showed anti-inflammatory activity although to a lesser extent as compared to indomethacin, however they were found less toxic than the latter. (c) 2007 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：1432 / 1437
页数：6
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