Synthesis and anti-inflammatory activity evaluation of unsymmetrical selenides

被引：14

作者：

Martinez-Ramos, Federico ^{[1
]}

Salgado-Zamora, Hector ^{[2
]}

Elena Campos-Aldrete, Maria ^{[2
]}

Melendez-Camargo, Estela ^{[3
]}

Marquez-Flores, Yazmin ^{[3
]}

Soriano-Garcia, Manuel ^{[4
]}

机构：

[1] Escuela Nacl Ciencias Biol, Dept Quim Inorgan, Mexico City 11340, DF, Mexico

[2] Escuela Nacl Ciencias Biol, Dept Quim Organ, Mexico City 11340, DF, Mexico

[3] Escuela Nacl Ciencias Biol, Dept Farm, Mexico City 11340, DF, Mexico

[4] Univ Nacl Autonoma Mexico, Dept Bioestruct, Inst Quim, CU, Mexico City 04510, DF, Mexico

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2008年 / 43卷 / 07期

关键词：

anti-inflammatory activity; alkylselenenyl benzoic acid derivatives; granuloma bioassay;

D O I：

10.1016/j.ejmech.2007.09.029

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The alkylation reaction of 2,2'-diseleno and 4,4'-diseleno-bis(benzoic acid) derivatives in the presence of sodium borohydride and alkyl halides allowed the synthesis of various new o- and p-alkylselenenylated benzoic acid derivatives in good yields. The anti-inflammatory activity of selected selenide derivatives on granuloma induced by subcutaneous implantation of cotton pellets in Wistar rats was examined. Selenium derivatives 2a, 2c and 2e showed anti-inflammatory activity although to a lesser extent as compared to indomethacin, however they were found less toxic than the latter. (c) 2007 Elsevier Masson SAS. All rights reserved.

引用

页码：1432 / 1437

页数：6

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