Hypertension and vascular dementia in the elderly: the potential role of anti-hypertensive agents

被引:15
作者
Coca, Antonio [1 ]
机构
[1] Univ Barcelona, Inst Med & Dermatol, Hosp Clin, E-08036 Barcelona, Spain
关键词
Anti-hypertensive agents; Cognitive decline; Hypertension; Vascular dementia; calcium channel blockers; BLOOD-PRESSURE; COGNITIVE FUNCTION; DOUBLE-BLIND; RISK-FACTORS; FOLLOW-UP; DECLINE; ASSOCIATION; MIDLIFE; PERINDOPRIL; PREVENTION;
D O I
10.1185/03007995.2013.813841
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Vascular dementia (VaD) - a severe form of vascular cognitive impairment - and cognitive decline are associated with hypertension and therefore it seems logical to consider that reducing BP with anti-hypertensive therapy may protect against the development/onset of cognitive function impairment or dementia. Scope: This narrative, non-systematic review discusses the available evidence on the potential correlation between the use of anti-hypertensive agents and the risk of VaD and cognitive decline. Methods: MEDLINE was searched for inclusion of relevant studies. No limitations in time were considered. Results: A consensus on the potential effects of anti-hypertensive treatment in the reduction of VaD and associated cognitive decline has not been reached. A protective effect of anti-hypertensive agents has been observed in a number of studies although it is still unclear whether different classes of anti-hypertensive agents have a different effect on the development of VaD. Conclusions: The protective effect of anti-hypertensive agents appears to depend on the specific drug used - positive effects have been observed with calcium channel blockers (CCBs), such as lercanidipine and nitrendipine, the combination perindopril-indapamide and telmisartan.
引用
收藏
页码:1045 / 1054
页数:10
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