Altered Default Mode Network Connectivity in Older Adults with Cognitive Complaints and Amnestic Mild Cognitive Impairment

被引：143
作者：
Wang, Yang [1 ]
Risacher, Shannon L. [1 ]
West, John D. [1 ]
McDonald, Brenna C. [1 ,2 ]
MaGee, Tamiko R. [1 ]
Farlow, Martin R. [2 ]
Gao, Sujuan [3 ]
O'Neill, Darren P. [1 ]
Saykin, Andrew J. [1 ]
机构：
[1] Indiana Univ Sch Med, Dept Radiol & Imaging Sci, Ctr Neuroimaging, Indianapolis, IN 46202 USA
[2] Indiana Univ Sch Med, Dept Neurol, Indianapolis, IN 46202 USA
[3] Indiana Univ Sch Med, Dept Biostat, Indianapolis, IN 46202 USA
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2013年 / 35卷 / 04期
基金：
美国国家卫生研究院;
关键词：
Alzheimer's disease; cognitive complaints; default mode network; functional connectivity; hippocampus; memory; mild cognitive impairment; WHITE-MATTER INTEGRITY; ALZHEIMERS-DISEASE; FUNCTIONAL CONNECTIVITY; SELECTIVE CHANGES; CORTICAL HUBS; BRAIN ATROPHY; STATE; DEMENTIA; MRI; MCI;
D O I：
10.3233/JAD-130080
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Default mode network (DMN) disruption has been reported in Alzheimer's disease (AD), yet the specific pattern of altered connectivity over the course of prodromal AD remains to be characterized. The aim of this study was to assess DMN connectivity in older adults with informant-verified cognitive complaints (CC) but normal neuropsychological performance compared to individuals with mild cognitive impairment (MCI) and healthy controls (HC). DMN maps were derived from resting-state fMRI using independent component analysis. Group comparisons of DMN connectivity were performed between older adults with MCI (n = 18), CC (n = 23), and HC (n = 16). Both CC and MCI showed decreased DMN connectivity in the right hippocampus compared to HC, with the CC group showing greater connectivity than MCI. These differences survived atrophy correction and correlated with cognitive performance. DMN connectivity appears sensitive to early prodromal neurodegenerative changes associated with AD, notably including pre-MCI individuals with cognitive complaints.
引用
收藏
页码：751 / 760
页数：10
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