In Vitro Activity of Methyl Gallate Isolated from Galla Rhois Alone and in Combination with Ciprofloxacin Against Clinical Isolates of Salmonella

被引：39

作者：

Choi, Jang-Gi ^{[2
]}

Kang, Ok-Hwa ^{[2
]}

Lee, Young-Seob ^{[2
]}

Oh, You-Chang ^{[2
]}

Chae, Hee-Sung ^{[2
]}

Jang, Hye-Jin ^{[2
]}

Kim, Jong Hak ^{[2
]}

Sohn, Dong-Hwan ^{[1
]}

Shin, Dong-Won ^{[3
]}

Park, Hyun ^{[4
]}

Kwon, Dong-Yeul ^{[1
,2
]}

机构：

[1] Wonkwang Univ, Coll Pharm, Dept Pharm, Chonbuk 570749, South Korea

[2] Wonkwang Univ, Wonkwang Oriental Med Res Inst, Chonbuk 570749, South Korea

[3] Sunchon Natl univ, Dept Oriental Med Resources, Sunchon 540742, South Korea

[4] Wonkwang Univ, Coll Med, Dept Parasitol, Chonbuk 570749, South Korea

来源：

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | 2008年 / 18卷 / 11期

关键词：

Salmonella; ciprofloxacin; methyl gallate; synergism;

D O I：

10.4014/jmb.0800.025

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Salmonella remains a primary cause of food poisoning worldwide, and massive outbreaks have been witnessed in recent years. Therefore, this study investigated the antimicrobial activity of methyl gallate (MG), which exhibited good antibacterial activity (MIC=3.9-125 mu g/ml) against all the bacterial strains tested. In a checkerboard dilution test, MG markedly lowered the MICs of ciprofloxacin (CPFX) against Salmonella. The combined activity of CPFX and MG against Salmonella resulted in fractional inhibitory concentrations (FICs) ranging from 0.0037 to 0.015 and from 0.24 to 7.8 mu g/ml, respectively. Meanwhile, the FIC index ranged from 0.31-0.37, indicating a marked synergistic relationship between CPFX and MG against Salmonella. Time-kill assays also showed a decrease in the CFU/ml between the combination and the more active compound. Therefore, this study demonstrated that MG and CPFX can act synergistically in inhibiting Salmonella in vitro.

引用

页码：1848 / 1852

页数：5

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