Tongguan Capsule Protects against Myocardial Ischemia and Reperfusion Injury in Mice

被引：13

作者：

Qi, Jianyong ^{[1
]}

Yu, Juan ^{[2
]}

Wang, Lei ^{[1
]}

Guo, Liheng ^{[1
]}

Ma, Shiyu ^{[1
]}

Huang, Donghui ^{[1
]}

Zhou, Miao ^{[3
]}

Wu, Jiashin ^{[4
]}

Zhang, Minzhou ^{[1
]}

机构：

[1] Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangdong Prov Hosp Chinese Med, Intens Care Lab, Guangzhou 510120, Guangdong, Peoples R China

[2] Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangdong Prov Hosp Chinese Med, Anim Lab, Guangzhou 510006, Guangdong, Peoples R China

[3] Guangzhou Med Univ, Stomatol Hosp, Dept Oral & Maxillary Surg, Guangzhou 510140, Guangdong, Peoples R China

[4] Univ S Florida, Tampa, FL 33612 USA

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2013年 / 2013卷

关键词：

NITRIC-OXIDE SYNTHASE; ASTRAGALOSIDE-IV; INFARCT SIZE; CARDIAC-FUNCTION; LATE-PHASE; CARDIOMYOCYTES; TEMPERATURE; EXPRESSION; OCCLUSION; PLAYS;

D O I：

10.1155/2013/159237

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Myocardial ischemia/reperfusion (I/R) can induce lethal ventricular arrhythmia and myocardial infarction. One of the clinical strategies for managing patients with high risk of myocardial I/R is to prevent the occurrence of arrhythmias and limit the size of infarction following a coronary episode. Tongguan Capsule (TGC) is one of the popular herbal remedies in treating coronary artery disease in the clinics of Chinese medicine. However, the potential roles and mechanisms of TGC in reducing I/R injury are still unclear. The present study statistically assessed the effectiveness of TGC in reducing I/R injury by comparing the infarct size (IS), risk region (RR), and arrhythmia (in electrocardiogram) among four groups of surgically created mice models of myocardial I/R: SHAM, I/R, VER (I/R with verapamil 20mg/kg pretreatment), and TGC (I/R with TGC 5 g/kg/d pretreatment). We found that IS was significantly smaller in the TGC and VER groups than I/R group, and the incidence of arrhythmias was reduced in the TGC group compared with I/R group, although there were no differences in RR among the four groups. We conclude that TGC is effective in reducing I/R injury in mice. These results provided an experimental basis for clinical application of TGC in reducing I/R injury.

引用

页数：8

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