Circulating microRNAs as diagnostic and prognostic tools for hepatocellular carcinoma

被引:57
作者
Zhang, Yu-Cheng [1 ]
Xu, Zhuo [2 ]
Zhang, Tian-Fu [3 ]
Wang, Ya-Li [4 ]
机构
[1] Jilin Univ, China Japan Union Hosp, Ctr Sci Res, Changchun 130033, Jilin Province, Peoples R China
[2] Jilin Univ, China Japan Union Hosp, Rehabil Dept, Changchun 130033, Jilin Province, Peoples R China
[3] Jilin Univ, China Japan Union Hosp, Dept Stomatol, Changchun 130033, Jilin Province, Peoples R China
[4] Jilin Univ, China Japan Union Hosp, Dept Blood Transfus, Changchun 130033, Jilin Province, Peoples R China
关键词
Circulating microRNAs; Diagnosis; Prognosis; Hepatocellular carcinoma; Biomarkers; HEPATITIS-C VIRUS; POTENTIAL BIOMARKERS; EMERGING BIOMARKERS; LIVER-DISEASES; NUCLEAR EXPORT; BODY-FLUIDS; CANCER; SERUM; CELLS; RNA;
D O I
10.3748/wjg.v21.i34.9853
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Hepatocellular carcinoma (HCC) is an aggressive malignancy and the second leading cause of cancer-related deaths worldwide. Conventional biomarkers exhibit poor performance in the surveillance, diagnosis, and prognosis of HCC. MicroRNAs (miRNAs) are a class of evolutionarily conserved small non-coding RNAs that are involved in the regulation of gene expression and protein translation, and they play critical roles in cell growth, differentiation, and the development of various types of cancers, including HCC. Recent evidence revealed the role of miRNAs as potential novel and ideal biomarkers for HCC. miRNAs are released to extracellular spaces, and they are extremely stable in bodily fluids, including serum or plasma, where they are packaged into various microparticles or associated with RNA-binding proteins. Numerous studies have demonstrated that circulating miRNAs have potential applications as minimally invasive biomarkers for HCC diagnosis and prognosis. The present review highlights current understanding of miRNA biogenesis and the origins and types of circulating miRNAs. We summarize recent progress in the use of circulating miRNAs as diagnostic and prognostic biomarkers for HCC. We also discuss the challenges and perspectives of the clinical utility of circulating miRNAs in HCC.
引用
收藏
页码:9853 / 9862
页数:10
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