MicroRNAs in platelet production and activation

被引：84

作者：

Edelstein, L. C. ^{[1
,2
]}

Mckenzie, S. E. ^{[1
,2
]}

Shaw, C. ^{[3
,4
,5
]}

Holinstat, M. A. ^{[1
,2
]}

Kunapuli, S. P. ^{[6
]}

Bray, P. F. ^{[1
,2
]}

机构：

[1] Thomas Jefferson Univ, Cardeza Fdn Hematol Res, Philadelphia, PA 19107 USA

[2] Thomas Jefferson Univ, Dept Med, Jefferson Med Coll, Philadelphia, PA 19107 USA

[3] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[4] Baylor Coll Med, Dept Med, Houston, TX 77030 USA

[5] Rice Univ, Dept Stat, Houston, TX 77251 USA

[6] Temple Univ, Sol Sherry Thrombosis Res Ctr, Sch Med, Philadelphia, PA 19122 USA

来源：

JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2013年 / 11卷

关键词：

biomarkers; megakaryocytes; megakaryopoiesis; microRNA; platelets; transcriptome; MESSENGER-RNAS; CIRCULATING MICRORNAS; CELL-DIFFERENTIATION; POLYCYTHEMIA-VERA; PROTEIN-SYNTHESIS; IN-VIVO; EXPRESSION; GENE; TRANSCRIPTION; PROGENITOR;

D O I：

10.1111/jth.12214

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent work by the Encyclopedia of DNA Elements project showed that non-protein-coding RNAs account for an unexpectedly large proportion of the human genome. Among these non-coding RNAs are microRNAs (miRNAs), which are small RNA molecules that modulate protein expression by degrading mRNA or repressing mRNA translation. MiRNAs have been shown to play important roles in hematopoiesis including embryonic stem cell differentiation, erythropoiesis, granulocytopoiesis/monocytopoiesis, lymphopoiesis, and megakaryocytopoiesis. Additionally, disordered miRNA biogenesis and quantitative or qualitative alterations in miRNAs and their targets are associated with hematological pathologies. Platelets contain machinery to process pre-miRNAs into mature miRNAs, and specific platelet miRNA levels have been found to correlate with platelet reactivity. This review summarizes the current state of knowledge of miRNAs in megakaryocytes and platelets, and the exciting possibilities for future megakaryocyte-platelet transcriptome research.

引用

页码：340 / 350

页数：11

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