Ligand-Free Synthesis of 1,4-Disubstituted-1,3-diynes by Iron/Copper Cocatalyzed Homocoupling of Terminal Alkynes

被引：15

作者：

Wang, Peipei ^{[1
]}

Liu, Xiaoyan ^{[1
]}

Zhang, Songlin ^{[1
]}

机构：

[1] Soochow Univ, Key Lab Organ Synth Jiangsu Prov, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Jiangsu, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2013年 / 31卷 / 02期

基金：

中国国家自然科学基金;

关键词：

catalysis; copper; iron; 1; 3-diyne; ligand-free; CATALYZED DIRECT ARYLATION; COUPLING REACTION; N-ARYLATION; IRON; EFFICIENT; DIMERIZATION; PANAXYTRIOL; CHLORIDE; SYSTEM; ARENES;

D O I：

10.1002/cjoc.201200878

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple and efficient protocol for Fe/Cu cocatalyzed oxidative homocoupling reaction of terminal alkynes to symmetrical 1,4-disubstituted-1,3-diynes was presented. The results showed that both CuBr and FeCl3 played crucial roles in the reaction. It is noteworthy that this protocol employs mild, efficient, aerobic and ligand free conditions. The alkynes, including aromatic, heteroaromatic and aliphatic alkynes, were transformed into the corresponding 1,3-diynes in good to excellent yields.

引用

页码：187 / 194

页数：8

共 77 条

[71] Total synthesis as a resource in drug discovery: The first in vivo evaluation of panaxytriol and its derivatives [J].