Synthesis, Thermosensitive Gelation and Degradation Study of a Biodegradable Triblock Copolymer

被引：6
|
作者：
Wang, Qin [1 ]
Wang, Chuandong [1 ]
Du, Xu [1 ]
Liu, Yang [1 ]
Ma, Lixia [1 ]
机构：
[1] Shandong Inst Med Instruments, Shandong Prov Key Lab Biomed Polymers, Jinan 250100, Peoples R China
来源：
JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY | 2013年 / 50卷 / 02期
关键词：
Biodegradable triblock copolymers; thermosensitive; hydrogel; degradation; PEG-PLA; HYDROLYTIC DEGRADATION; CONTROLLED-RELEASE; BLOCK-COPOLYMERS; ETHYLENE-OXIDE; NANOPARTICLES; HOMOPOLYMERS; ASSOCIATION; DIFFUSION;
D O I：
10.1080/10601325.2013.742794
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
A series of biodegradable triblock copolymers PLA-PEG-PLA were synthesized by ring-opening polymerization of D,L-lactide using PEG as initiator. The structures and molecular weights of the triblock copolymers were characterized by1H-NMR and GPC.Their thermal properties were tested by DSC. The thermosensitive gelation behaviors and hydrolytic degradation were investigated. Sol-gel transition was observed with proper LA/EG ratios from 2.23 to 2.57. Besides, the sol-gel transition temperature has a close relation with the concentration and molecular weight of the triblock copolymers. The hydrolytic degradation experiment indicates the copolymers with lower LA/EG ratios degrade faster, and the degradation probably occurred at the PLA block at random.
引用
收藏
页码：200 / 207
页数：8
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