The therapeutic phase I trial of the recombinant native HIV-1 Tat protein

被引：38

作者：

Ensoli, Barbara ^{[1
]}

Fiorelli, Valeria ^{[1
]}

Ensoli, Fabrizio ^{[2
]}

Lazzarin, Adriano ^{[3
]}

Visintini, Raffaele ^{[3
]}

Narciso, Pasquale ^{[4
]}

Di Carlo, Aldo ^{[2
]}

Monini, Paolo ^{[1
]}

Magnani, Mauro ^{[5
]}

Garaci, Enrico

机构：

[1] Ist Super Sanita, Natl AIDS Ctr, I-00161 Rome, Italy

[2] San Gallicano Hosp, Rome, Italy

[3] Hosp San Raffaele, I-20132 Milan, Italy

[4] Natl Inst Infect Dis L Spallanzani, Rome, Italy

[5] Univ Urbino, I-61029 Urbino, Italy

来源：

AIDS | 2008年 / 22卷 / 16期

关键词：

D O I：

10.1097/QAD.0b013e32831392d4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The native HIV-1 Tat protein was chosen as a vaccine candidate based on its key role in the virus life cycle and on the correlation of Tat-specific immune responses with the asymptomatic stage and lower disease progression rates, but also due to its sequence conservation amongst the various HIV clades as well as the adjuvant effects on dendritic cells. Safety, immunogenicity and efficacy data in monkeys support the development of this vaccine concept.

引用

页码：2207 / 2209

页数：3

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