Parameters predicting complications in flap surgery

被引：19

作者：

Handschel, Joerg ^{[1
]}

Burghardt, Stefan ^{[1
]}

Naujoks, Christian ^{[1
]}

Kuebler, Norbert R. ^{[1
]}

Giers, Guenter ^{[2
]}

机构：

[1] Univ Dusseldorf, Dept Cranio & Maxillofacial Surg, D-40225 Dusseldorf, Germany

[2] Univ Dusseldorf, Fac Med, Dept Lab Med, D-40225 Dusseldorf, Germany

来源：

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY | 2013年 / 115卷 / 05期

关键词：

VON-WILLEBRAND-FACTOR; ACTIVATED PROTEIN-C; POOR ANTICOAGULANT RESPONSE; FACTOR-VIII; COAGULATION-FACTOR; VENOUS THROMBOSIS; RISK; HEAD; THROMBOPHILIA; FIBRINOGEN;

D O I：

10.1016/j.oooo.2012.09.007

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Objectives. The aim of this prospective study was to determine laboratory parameters predicting complications and/or failure in flap surgery. Study Design. Fifty-seven patients undergoing reconstructive surgery with cutaneous free and pedicled flaps were included. Blood samples were taken 2 days before surgery and 1, 3, 5, 7, and 14 days after. Parameters associated with thrombophilia, bleeding disorders, and wound healing were determined. Results. In 45 (77%) of 57 patients no complications occurred. Bleeding (9%) and venous thrombosis of the flaps (9%) led in 18% of the cases to surgical revisions. Activated protein C resistance showed a significant (P < .05) cluster in cases with venous thrombosis, whereas it was absent in all other cases. Fibrinogen, factor VIII:C, von Willebrand factor (vWF) activity, and VWF antigen were significantly (P < .05) higher in patients with venous thrombosis compared with all other patients. Conclusions. Laboratory parameters of thrombosis and bleeding appear to be associated with complications in flap surgery.

引用

页码：589 / 594

页数：6

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