Lipid-Lowering Therapy is Related to Inflammatory Markers and 3-Year Mortality in Patients With Critical Limb Ischemia

被引：19
|
作者：
Isma, Nazim [1 ]
Barani, Jamal [1 ]
Mattiasson, Ingrid [1 ]
Lindblad, Bengt [1 ]
Gottsaeter, Anders [1 ]
机构：
[1] Lund Univ, Dept Vasc Dis, Malmo Univ Hosp, S-20502 Malmo, Sweden
来源：
ANGIOLOGY | 2008年 / 59卷 / 05期
关键词：
critical limb ischemia; inflammation; risk factors; lipid lowering; statin;
D O I：
10.1177/0003319707306144
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
To evaluate relationships between lipid-lowering therapy, inflammation, and 3-year mortality in critical limb ischemia (CLI), 259 consecutive CLI patients underwent evaluation of medication, tumor necrosis factor-alpha, interleukin-6 (IL-6), neopterin, high-sensitivity C-reactive protein (hs-CRP), 8-epi-PGF(2 alpha), and endothelin-1. Mortality was assessed after 3 years. Sixty-one patients (24%) were on lipid-lowering therapy and 59 patients (97%) on statins. Patients on lipid-lowering therapy were younger and showed lower low-density lipoprotein cholesterol, hs-CRP, and IL-6 levels than patients without therapy. Three-year survival was higher among patients on lipid-lowering therapy, In logistic regression, the effect of lipid-lowering therapy on 3-year survival was significant with inflammatory markers entered into the model one by one but disappeared when all inflammatory markers were entered into the model together. In conclusion, hs-CRP and IL-6 levels were lower and 3-year survival was higher in CLI patients on lipid-lowering therapy
引用
收藏
页码：542 / 548
页数：7
相关论文
共 18 条
  • [1] The effect of aggressive versus conventional lipid-lowering therapy on markers of inflammatory and oxidative stress
    Mulder, Douwe J.
    van Haelst, Paul L.
    Wobbes, Martgriet H.
    Gans, Rijk O.
    Zijlstra, Felix
    May, Johan F.
    Smit, Andries J.
    Tervaert, Jan Willem Cohen
    van Doormaal, Jasper J.
    CARDIOVASCULAR DRUGS AND THERAPY, 2007, 21 (02) : 91 - 97
  • [2] The Effect of Aggressive Versus Conventional Lipid-lowering Therapy on Markers of Inflammatory and Oxidative Stress
    Douwe J. Mulder
    Paul L. van Haelst
    Martgriet H. Wobbes
    Rijk O. Gans
    Felix Zijlstra
    Johan F. May
    Andries J. Smit
    Jan Willem Cohen Tervaert
    Jasper J. van Doormaal
    Cardiovascular Drugs and Therapy, 2007, 21 : 91 - 97
  • [3] Effect of Intensive Lipid-Lowering Therapy on Cardiovascular Outcome in Patients With and Those Without Inflammatory Joint Disease
    Semb, Anne Grete
    Kvien, Tore K.
    DeMicco, David A.
    Fayyad, Rana
    Wun, Chuan-Chuan
    LaRosa, John C.
    Betteridge, John
    Pedersen, Terje R.
    Holme, Ingar
    ARTHRITIS AND RHEUMATISM, 2012, 64 (09): : 2836 - 2846
  • [4] Ten-year Risk of Atherosclerotic Cardiovascular Disease Predicts Long-Term Mortality in Lipid-Lowering Therapy
    Ma, Zhiyuan
    Moran, Lynn N.
    Shirani, Jamshid
    CIRCULATION, 2023, 148
  • [5] The relationship between sarcopenia and one-year mortality in patients with critical limb ischemia undergoing endovascular therapy below the knee
    Guler, Arda
    Gurbak, Ismail
    Aydin, Sinem
    Kahraman, Serkan
    Tasbulak, Omer
    Ucar, Servet U.
    Dogan, Arda C.
    Topel, Cagdas
    Panc, Cafer
    Cizgici, Ahmet Y.
    Kalkan, Ali K.
    Yalcin, Ahmet A.
    Erturk, Mehmet
    VASCULAR, 2023, 31 (03) : 513 - 520
  • [6] Prognostic factor of the two-year mortality after revascularization in patients with critical limb ischemia
    Morisaki, Koichi
    Matsumoto, Takuya
    Matsubara, Yutaka
    Inoue, Kentaro
    Aoyagi, Yukihiko
    Matsuda, Daisuke
    Tanaka, Shinichi
    Okadome, Jun
    Maehara, Yoshihiko
    VASCULAR, 2017, 25 (02) : 123 - 129
  • [7] 3-Year Outcomes of the OLIVE Registry, a Prospective Multicenter Study of Patients With Critical Limb Ischemia A Prospective, Multi-Center, Three-Year Follow-Up Study on Endovascular Treatment for Infra-Inguinal Vessel in Patients With Critical Limb Ischemia
    Iida, Osamu
    Nakamura, Masato
    Yamauchi, Yasutaka
    Fukunaga, Masashi
    Yokoi, Yoshiaki
    Yokoi, Hiroyoshi
    Soga, Yoshimistu
    Zen, Kan
    Suematsu, Nobuhiro
    Inoue, Naoto
    Suzuki, Kenji
    Hirano, Keisuke
    Shintani, Yoshiaki
    Miyashita, Yusuke
    Urasawa, Kazushi
    Kitano, Ikuro
    Tsuchiya, Taketsugu
    Kawamoto, Kenji
    Yamaoka, Terutoshi
    Uesugi, Michitaka
    Shinke, Toshiro
    Oba, Yasuhiro
    Ohura, Norihiko
    Uematsu, Masaaki
    Takahara, Mitsuyoshi
    Hamasaki, Toshimitsu
    Nanto, Shinsuke
    JACC-CARDIOVASCULAR INTERVENTIONS, 2015, 8 (11) : 1493 - 1502
  • [8] Risk Stratification of Perioperative and Long-Term Mortality in Patients With Critical Limb Ischemia Undergoing Endovascular Therapy
    Hata, Yosuke
    Iida, Osamu
    Asai, Mitsutoshi
    Masuda, Masaharu
    Okamoto, Shin
    Ishihara, Takayuki
    Nanto, Kiyonori
    Kanda, Takashi
    Tsujimura, Takuya
    Okuno, Shota
    Matsuda, Yoshihiro
    Kawai, Hiroyuki
    Tsuji, Aki
    Sato, Yuki
    Uematsu, Hiroyuki
    Toyoshima, Taku
    Higashino, Naoko
    Mano, Toshiaki
    CIRCULATION, 2018, 138
  • [9] Beneficial Changes of Serum Calcification Markers and Contralateral Carotid Plaques Echogenicity after Combined Carotid Artery Stenting Plus Intensive Lipid-lowering Therapy in Patients with Bilateral Carotid Stenosis
    Kadoglou, N. P. E.
    Gerasimidis, T.
    Kapelouzou, A.
    Moumtzouoglou, A.
    Avgerinos, E. D.
    Kakisis, J. D.
    Karayannacos, P. E.
    Liapis, C. D.
    EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, 2010, 39 (03) : 258 - 265
  • [10] Predictive value of admission blood pressure for 3-month mortality in patients undergoing revascularization for critical limb ischemia
    Yannoutsos, Alexandra
    Lin, Franck
    Billuart, Olivier
    Gaisset, Roxane
    Sacco, Emmanuelle
    Beaussier, Helene
    Buronfosse, Anne
    Mourad, Jean-Jacques
    Emmerich, Joseph
    Lazareth, Isabelle
    Priollet, Pascal
    JOURNAL OF HYPERTENSION, 2020, 38 (12) : 2409 - 2415
12