Rethinking Glioblastoma Therapy: MDA-9/Syntenin Targeted Small Molecule

被引：13

作者：

Das, Swadesh K. ^{[1
,2
,3
]}

Sarkar, Devanand ^{[1
,2
,3
]}

Cavenee, Webster K. ^{[4
]}

Emdad, Luni ^{[1
,2
,3
]}

Fisher, Paul B. ^{[1
,2
,3
]}

机构：

[1] Virginia Commonwealth Univ, Dept Human & Mol Genet, Sch Med, Richmond, VA 23298 USA

[2] Virginia Commonwealth Univ, Sch Med, VCU Inst Mol Med, Richmond, VA 23298 USA

[3] Virginia Commonwealth Univ, Sch Med, VCU Massey Canc Ctr, Richmond, VA 23298 USA

[4] Univ Calif San Diego, Ludwig Inst Canc Res, San Diego, CA 92093 USA

来源：

ACS CHEMICAL NEUROSCIENCE | 2019年 / 10卷 / 03期

关键词：

Glioblastoma multiforme; MDA-9/Syntenin; invasion; pathogenicity;

D O I：

10.1021/acschemneuro.9b00016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Effective therapies for glioblastoma multiforme (GBM) are not currently available. A small molecule has been identified using fragment-based drug-discovery guided by NMR that targets important protein-protein interactions controlling GBM invasion and pathogenicity. This first generation drug displays excellent pharmacokinetic properties, passes through the blood-brain barrier and is effective in preclinical animal models of GBM, particularly when combined with radiation therapy.

引用

页码：1121 / 1123

页数：5

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