Targeting TGF-β Signaling in Cancer

被引：753

作者：

Colak, Selcuk ^{[1
]}

ten Dijke, Peter ^{[1
,2
,3
]}

机构：

[1] Leiden Univ, Dept Mol Cell Biol, Canc Genom Ctr Netherlands, Med Ctr, Postbus 9600, NL-2300 RC Leiden, Netherlands

[2] Uppsala Univ, Ludwig Inst Canc Res, Sci Life Lab, Uppsala, Sweden

[3] Univ Tsukuba, Dept Canc Signaling, Fac Med, Tsukuba, Ibaraki 3058575, Japan

来源：

TRENDS IN CANCER | 2017年 / 3卷 / 01期

关键词：

GROWTH-FACTOR-BETA; CIRCULATING TUMOR-CELLS; TO-MESENCHYMAL TRANSITION; GALUNISERTIB LY2157299 MONOHYDRATE; I KINASE INHIBITOR; COLORECTAL-CANCER; POOR-PROGNOSIS; RECEPTOR-I; MICROSATELLITE INSTABILITY; LUNG METASTASIS;

D O I：

10.1016/j.trecan.2016.11.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The transforming growth factor (TGF)-beta signaling pathway is deregulated in many diseases, including cancer. In healthy cells and early-stage cancer cells, this pathway has tumor-suppressor functions, including cell-cycle arrest and apoptosis. However, its activation in late-stage cancer can promote tumorigenesis, including metastasis and chemoresistance. The dual function and pleiotropic nature of TGF-beta signaling make it a challenging target and imply the need for careful therapeutic dosing of TGF-beta drugs and patient selection. We review here the rationale for targeting TGF-beta signaling in cancer and summarize the clinical status of pharmacological inhibitors. We discuss the direct effects of TGF-beta signaling blockade on tumor and stromal cells, as well as biomarkers that can predict the efficacy of TGF-beta inhibitors in cancer patients.

引用

页码：56 / 71

页数：16

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