Targeting TGF-β Signaling in Cancer

被引：753
作者：
Colak, Selcuk [1 ]
ten Dijke, Peter [1 ,2 ,3 ]
机构：
[1] Leiden Univ, Dept Mol Cell Biol, Canc Genom Ctr Netherlands, Med Ctr, Postbus 9600, NL-2300 RC Leiden, Netherlands
[2] Uppsala Univ, Ludwig Inst Canc Res, Sci Life Lab, Uppsala, Sweden
[3] Univ Tsukuba, Dept Canc Signaling, Fac Med, Tsukuba, Ibaraki 3058575, Japan
来源：
TRENDS IN CANCER | 2017年 / 3卷 / 01期
关键词：
GROWTH-FACTOR-BETA; CIRCULATING TUMOR-CELLS; TO-MESENCHYMAL TRANSITION; GALUNISERTIB LY2157299 MONOHYDRATE; I KINASE INHIBITOR; COLORECTAL-CANCER; POOR-PROGNOSIS; RECEPTOR-I; MICROSATELLITE INSTABILITY; LUNG METASTASIS;
D O I：
10.1016/j.trecan.2016.11.008
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The transforming growth factor (TGF)-beta signaling pathway is deregulated in many diseases, including cancer. In healthy cells and early-stage cancer cells, this pathway has tumor-suppressor functions, including cell-cycle arrest and apoptosis. However, its activation in late-stage cancer can promote tumorigenesis, including metastasis and chemoresistance. The dual function and pleiotropic nature of TGF-beta signaling make it a challenging target and imply the need for careful therapeutic dosing of TGF-beta drugs and patient selection. We review here the rationale for targeting TGF-beta signaling in cancer and summarize the clinical status of pharmacological inhibitors. We discuss the direct effects of TGF-beta signaling blockade on tumor and stromal cells, as well as biomarkers that can predict the efficacy of TGF-beta inhibitors in cancer patients.
引用
收藏
页码：56 / 71
页数：16
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