RIFM fragrance ingredient safety assessment, dipropyl disulfide, CAS Registry Number 629-19-6

被引：1

作者：

Api, A. M. ^{[1
]}

Belsito, D. ^{[2
]}

Biserta, S. ^{[1
]}

Botelho, D. ^{[1
]}

Bruze, M. ^{[3
]}

Burton, G. A., Jr. ^{[4
]}

Buschmann, J. ^{[5
]}

Cancellieri, M. A. ^{[1
]}

Dagli, M. L. ^{[6
]}

Date, M. ^{[1
]}

Dekant, W. ^{[7
]}

Deodhar, C. ^{[1
]}

Fryer, A. D. ^{[8
]}

Gadhia, S. ^{[1
]}

Jones, L. ^{[1
]}

Joshi, K. ^{[1
]}

Lapczynski, A. ^{[1
]}

Lavelle, M. ^{[1
]}

Liebler, D. C. ^{[9
]}

Na, M. ^{[1
]}

O'Brien, D. ^{[1
]}

Patel, A. ^{[1
]}

Penning, T. M. ^{[10
]}

Ritacco, G. ^{[1
]}

Rodriguez-Ropero, F. ^{[1
]}

Romine, J. ^{[1
]}

Sadekar, N. ^{[1
]}

Salvito, D. ^{[1
]}

Schultz, T. W. ^{[11
]}

Siddiqi, F. ^{[1
]}

Sipes, I. G. ^{[12
]}

Sullivan, G. ^{[1
]}

Thakkar, Y. ^{[1
]}

Tokura, Y. ^{[13
,14
]}

Tsang, S. ^{[1
]}

机构：

[1] Res Inst Fragrance Mat Inc, 50 Tice Blvd, Woodcliff Lake, NJ 07677 USA

[2] Columbia Univ, Dept Dermatol, RIFM Expert Panel, Med Ctr, 161 Ft Washington Ave, New York, NY 10032 USA

[3] Malmo Univ Hosp, Dept Occupat & Environm Dermatol, RIFM Expert Panel, Sodra Forstadsgatan 101,Entrance 47, SE-20502 Malmo, Sweden

[4] Univ Michigan, RIFM Expert Panel, Sch Nat Resources & Environm, Dana Bldg G110,440 Church St, Ann Arbor, MI 58109 USA

[5] Fraunhofer Inst Toxicol & Expt Med, RIFM Expert Panel, Nikolai Fuchs Str 1, D-30625 Hannover, Germany

[6] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, RIFM Expert Panel, Av Prof Dr Orlando Marques de Paiva 87, BR-05508900 Sao Paulo, Brazil

[7] Univ Wurzburg, Dept Toxicol, RIFM Expert Panel, Versbacher Str 9, D-97078 Wurzburg, Germany

[8] Oregon Hlth & Sci Univ, RIFM Expert Panel, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

[9] Vanderbilt Univ, Ctr Mol Toxicol, Dept Biochem, RIFM Expert Panel,Sch Med, 638 Robinson Res Bldg,2200 Pierce Ave, Nashville, TN 37232 USA

[10] Univ Penn, Ctr Excellence Environm Toxicol, Perelman Sch Med, RIFM Expert Panel, 1316 Biomed Res Bldg BRB 2-3,421 Curie Blvd, Philadelphia, PA 19104 USA

[11] Univ Tennessee, Coll Vet Med, Dept Comparat Med, RIFM Expert Panel, 2407 River Dr, Knoxville, TN 37996 USA

[12] Univ Arizona, Coll Med, Dept Pharmacol, RIFM Expert Panel, 1501 North Campbell Ave,POB 245050, Tucson, AZ 85724 USA

[13] Hamamatsu Univ Sch Med, RIFM Expert Panel, Journal Dermatol Sci JDS, Higashi Ku, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313192, Japan

[14] Hamamatsu Univ Sch Med, Dept Dermatol, Higashi Ku, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313192, Japan

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2020年 / 141卷

关键词：

DERMAL SENSITIZATION THRESHOLD; PERSONAL CARE; DST APPROACH; CONSUMER EXPOSURE; MODEL; ABSORPTION; COSMETICS; CHEMICALS; TTC;

D O I：

10.1016/j.fct.2020.111423

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The existing information supports the use of this material as described in this safety assessment. Dipropyl disulfide was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog dimethyl disulfide (CAS # 624-92-0) show that dipropyl disulfide is not expected to be genotoxic and provide a calculated margin of exposure (MOE) > 100 for the repeated dose toxicity and reproductive toxicity endpoints. The skin sensitization endpoint was completed using the dermal sensitization threshold (DST) for reactive materials (64 pg/cm 2 ); exposure is below the DST. The phototoxicity/photoallergenicity endpoints were evaluated based on ultraviolet (UV) spectra; dipropyl disulfide is not expected to be phototoxic/photoallergenic. The local respiratory toxicity endpoint was evaluated using the threshold of toxicological concern (TTC) for a Cramer Class I material, and the exposure to dipropyl disulfide is below the TTC (1.4 mg/day). The environmental endpoints were evaluated; dipropyl disulfide was found not to be persistent, bioaccumulative, and toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are < 1.

引用

页数：10

共 39 条

[1] [Anonymous], EFSA J, DOI [10.2903/j.efsa.2010.1337, DOI 10.2903/J.EFSA.2010.1337]
[2] [Anonymous], 2015, Guidance Document on Revisions to OECD Genetic Toxicology Test Guidelines
[3] [Anonymous], 2012, GUIDANCE INFORM REQU
[4] Api A M, 2015, Food Chem Toxicol, V82 Suppl, pS1, DOI 10.1016/j.fct.2014.11.014
[5] Comparison of Cramer classification between Toxtree, the OECD QSAR Toolbox and expert judgment
Bhatia, Sneha
Schultz, Terry
Roberts, David
Shen, Jie
Kromidas, Lambros
Api, Anne Marie
[J]. REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2015, 71 (01) : 52 - 62
[6] Exposure based waiving: The application of the toxicological threshold of concern (TTC) to inhalation exposure for aerosol ingredients in consumer products
Carthew, P.
Clapp, C.
Gutsell, S.
[J]. FOOD AND CHEMICAL TOXICOLOGY, 2009, 47 (06) : 1287 - 1295
[7] CAESAR models for developmental toxicity
Cassano, Antonio
Manganaro, Alberto
Martin, Todd
Young, Douglas
Piclin, Nadege
Pintore, Marco
Bigoni, Davide
Benfenati, Emilio
[J]. CHEMISTRY CENTRAL JOURNAL, 2010, 4
[8] Integrating habits and practices data for soaps, cosmetics and air care products into an existing aggregate exposure model
Comiskey, D.
Api, A. M.
Barrett, C.
Ellis, G.
McNamara, C.
O'Mahony, C.
Robison, S. H.
Rose, J.
Safford, B.
Smith, B.
Tozer, S.
[J]. REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2017, 88 : 144 - 156
[9] Novel database for exposure to fragrance ingredients in cosmetics and personal care products
Comiskey, D.
Api, A. M.
Barratt, C.
Daly, E. J.
Ellis, G.
McNamara, C.
O'Mahony, C.
Robison, S. H.
Safford, B.
Smith, B.
Tozer, S.
[J]. REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2015, 72 (03) : 660 - 672
[10] CRAMER GM, 1978, FOOD COSMET TOXICOL, V16, P255, DOI 10.1016/S0015-6264(76)80522-6

← 1 2 3 4 →