Nutrient detection by incretin hormone secreting cells

被引：94
作者：
Diakogiannaki, Eleftheria
Gribble, Fiona M.
Reimann, Frank [1 ]
机构：
[1] Addenbrookes Hosp, Cambridge Inst Med Res, Cambridge CB2 0XY, England
来源：
PHYSIOLOGY & BEHAVIOR | 2012年 / 106卷 / 03期
基金：
英国惠康基金; 英国医学研究理事会; 英国生物技术与生命科学研究理事会;
关键词：
Glucose-dependent insulinotropic polypeptide (GIP); Glucagon-like peptide-1 (GLP-1); Intestinal K-cells; Intestinal L-cells; Nutrient sensing; GLUCAGON-LIKE PEPTIDE-1; GASTRIC-INHIBITORY POLYPEPTIDE; DEPENDENT INSULINOTROPIC POLYPEPTIDE; TYPE-2; DIABETES-MELLITUS; AMINO-ACID PERFUSION; G-PROTEIN; HEALTHY-SUBJECTS; TASTE RECEPTORS; FATTY-ACIDS; GASTROINTESTINAL-TRACT;
D O I：
10.1016/j.physbeh.2011.12.001
中图分类号：
B84 [心理学];
学科分类号：
04 ; 0402 ;
摘要：
The hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulintropic polypeptide (GIP) are secreted after a meal. Like other enteroendocrine hormones they help to orchestrate the bodies' response to the availability of newly absorbable nutrients and are noteworthy as they stimulate postprandial insulin secretion, underlying what is known as the incretin effect. GLP-1-mimetics are now widely used in the treatment of type 2 diabetes and advantages over older insulinotropic therapies include weight loss. An alternative treatment regime might be the recruitment of endogenous GLP-1, however, very little is known about the physiological control of enteroendocrine responses. This review focuses on the molecular mechanisms to detect nutrient arrival in the gut that have been implicated within the incretin secreting cells. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：387 / 393
页数：7
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