Integrated one-day surveillance of antimicrobial use, antimicrobial consumption, antimicrobial resistance, healthcare-associated infection, and antimicrobial resistance burden among hospitalized patients in Thailand

被引:8
作者
Thamlikitkul, Visanu [1 ,2 ]
Rattanaumpawan, Pinyo [1 ,2 ]
Sirijatuphat, Rujipas [1 ,2 ]
Wangchinda, Walaiporn [1 ,2 ]
机构
[1] Mahidol Univ, Fac Med, Div Infect Dis & Trop Med, Dept Med,Siriraj Hosp, 2 Wanglang Rd, Bangkok 10700, Thailand
[2] Mahidol Univ, Fac Med, World Hlth Org Collaborating Ctr Antimicrobial Re, Siriraj Hosp, 2 Wanglang Rd, Bangkok 10700, Thailand
关键词
Surveillance; Antimicrobial resistance; Antimicrobial use; Antimicrobial consumption; Healthcare-associated infection; Burden; ANTIBIOTIC USE; PREVALENCE;
D O I
10.1016/j.jinf.2020.04.040
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Objectives: Surveillance of antimicrobial use (AMU), antimicrobial consumption (AMC), antimicrobial resistance (AMR), healthcare-associated infection (HAI), and AMR burden are usually measured by time-consuming and expensive multiple separate longitudinal surveys. This study aimed to investigate feasibility and benefit of integrated one-day surveillance to estimate and monitor these parameters. Methods: Integrated one-day surveillance of AMU, AMC, AMR, HAI, and AMR burden among hospitalized patients in 183 hospitals in Thailand was conducted. Parameter data was collected for each patient who received antibiotic on a survey day. Results: AMU prevalence was 51.5% among 23,686 hospitalized patients. The most commonly used antibiotic for infection prophylaxis and treatment was cefazolin and ceftriaxone, respectively. The most common infection was pneumonia. Community-associated infection (CAI) was observed in 64.9%, and 34.1% had HAI. Prevalence of AMR was highest in A. baumannii infection. AMR in bacteria was more prevalent among HAI than among CAL Consumption of all antibiotics was 18,103 defined daily doses. HAI prevalence was 14.0%. Health and economic burden were much higher in patients with antibiotic-resistant infection. Conclusions: Integrated one-day surveillance of these important parameters among hospitalized patients is feasible and can be used for estimation and monitoring from the facility-level to the national-level in resource-limited settings. (C) 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:98 / 106
页数:9
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