Plant-derived compounds: A potential source of drugs against Tobacco mosaic virus

被引：23

作者：

Cai, Lin ^{[1
]}

Zhang, Wang ^{[1
]}

Jia, Huanyu ^{[1
]}

Feng, Hui ^{[1
]}

Wei, Xuefeng ^{[1
]}

Chen, Haitao ^{[4
]}

Wang, Daibin ^{[4
]}

Xue, Yang ^{[2
,3
]}

Sun, Xianchao ^{[1
]}

机构：

[1] Southwest Univ, Coll Plant Protect, Chongqing 400715, Peoples R China

[2] Southwest Univ, Citrus Res Inst, Chongqing 400712, Peoples R China

[3] Southwest Univ, Sch Chem & Chem Engn, Chongqing 400715, Peoples R China

[4] Chongqing Tobacco Sci Res Inst, Chongqing 400715, Peoples R China

来源：

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY | 2020年 / 169卷

基金：

中国国家自然科学基金;

关键词：

Ursolic acid; 4-methoxycoumarin; Tobacco mosaic virus; Antiviral mechanism; Induced resistance; SALICYLIC-ACID; JASMONIC ACID; SYSTEMIC RESISTANCE; SULFATED LENTINAN; URSOLIC ACID; COUMARINS; SUBSTANCES; PESTICIDES; DEFENSE; TMV;

D O I：

10.1016/j.pestbp.2020.104589

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tobacco mosaic virus (TMV) is an important plant virus that led to significant losses in the crops worldwide. In this study, the antiviral activities of Ursolic Acid (UA) and 4-methoxycoumarin against TMV and their underlying mechanisms were initially investigated for the first time. The results demonstrated that the antiviral effects of UA and 4-methoxycoumarin were as effective as those of the commercial agent lentinan, in either the protective effect, inactivation effect or curative effect. In addition, both plant-derived compounds could induce the resistance responses of tobacco plants against TMV, showing increased antioxidant enzyme activities (SOD and POD) and H2O2 accumulation in tobacco leaves after treatment with UA or 4-methoxycoumarin, along with highly expressed regulatory and defence genes in the salicylic acid signaling pathway. Meanwhile, electrolyte leakage and malondialdehyde experiments indicated that these effects did not result in phytotoxicity or damage to the leaf plasma membrane of tobacco plants. Collectively, the results demonstrate that UA and 4-methoxycoumarin have potential as eco-friendly and safe strategies to control TMV in the future.

引用

页数：10

共 49 条

[1] Emerging microbial biocontrol strategies for plant pathogens [J].

Ab Rahman, Sharifah Farhana Syed ;

Singh, Eugenie ;

Pieterse, Come M. J. ;

Schenk, Peer M. .

PLANT SCIENCE, 2018, 267 :102-111

[2]

Al-Wakeel S. M., 2013, Acta Agronomica Hungarica, V61, P23, DOI 10.1556/AAgr.61.2013.1.3

[3] Anticoagulant sulfated polysaccharides: Part I. Synthesis and structure-activity relationships of new pullulan sulfates [J].

Alban, S ;

Schauerte, A ;

Franz, G .

CARBOHYDRATE POLYMERS, 2002, 47 (03) :267-276

[4] The NONEXPRESSOR OF PATHOGENESIS-RELATED GENES 1 (NPR1) and Related Family: Mechanistic Insights in Plant Disease Resistance [J].

Backer, Robert ;

Naidoo, Sanushka ;

van den Berg, Noelani .

FRONTIERS IN PLANT SCIENCE, 2019, 10

[5] Signaling in plant-microbe interactions [J].

Baker, B ;

Zambryski, P ;

Staskawicz, B ;

DineshKumar, SP .

SCIENCE, 1997, 276 (5313) :726-733

[6] Recent advances and therapeutic journey of coumarins: current status and perspectives [J].

Barot, Kuldipsinh P. ;

Jain, Shailesh V. ;

Kremer, Laurent ;

Singh, Shubhra ;

Ghate, Manjunath D. .

MEDICINAL CHEMISTRY RESEARCH, 2015, 24 (07) :2771-2798

[7] The battle for survival between viruses and their host plants [J].

Boualem, Adnane ;

Dogimont, Catherine ;

Bendahmane, Abdelhafid .

CURRENT OPINION IN VIROLOGY, 2016, 17 :32-38

[8]

Cai L., 2018, MOLECULES, V23

[9] Ursolic acid from apple pomace and traditional plants: A valuable triterpenoid with functional properties [J].

Cargnin, Simone Tasca ;

Gnoatto, Simone Baggio .

FOOD CHEMISTRY, 2017, 220 :477-489

[10] Pesticides, environment, and food safety [J].

Carvalho, Fernando P. .

FOOD AND ENERGY SECURITY, 2017, 6 (02) :48-60

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