Electrochemotherapy for the treatment of squamous cell carcinoma in cats: A preliminary report

被引：41

作者：

Spugnini, Enrico P. ^{[1
]}

Vincenzi, Bruno ^{[2
]}

Citro, Gennaro ^{[1
]}

Tonini, Giuseppe ^{[2
]}

Dotsinsky, Ivan ^{[3
]}

Mudrov, Nikolay ^{[3
]}

Baldi, Alfonso ^{[1
,4
]}

机构：

[1] Regina Elena Inst Canc Res, SAFU Dept, I-00158 Rome, Italy

[2] Univ Campus Biomed, Rome, Italy

[3] Ctr Biomed Engn, Sofia, Bulgaria

[4] Univ Naples 2, Sect Pathol, Dept Biochem, Naples, Italy

来源：

VETERINARY JOURNAL | 2009年 / 179卷 / 01期

关键词：

Bleomycin; Carcinoma; Electrochemotherapy; Feline; Hyaluronidase; NASAL PLANUM; PHOTODYNAMIC THERAPY; TUMORS; CHEMOTHERAPY; ANIMALS; PULSES; MODEL;

D O I：

10.1016/j.tvjl.2007.08.011

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Squamous cell carcinomas (SCC) of the skin are commonly described in cats. Reported treatments include Surgery, radiation therapy and photodynamic therapy. This preliminary Study reports on the management of these lesions combining the local administration of bleomycin (,Plus hyaluronidase for a more uniform distribution) With permeabilizing biphasic electric pulses. Nine cats with SCC graded T-2-T-4 were treated over a 5 year period, and each cat received two sessions of electrochemotherapy (ECT) 1 week apart. The side effects of this treatment were minimal and limited to mild erythema of the nose. Seven of the cats (77.7%) had a complete response lasting tip to 3 years. ECT seems to be a safe and effective option for the treatment of feline sun-induced squamous cell carcinomas and warrants further investigation. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：117 / 120

页数：4

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