First-in-man Phase I trial of BYK408740, an oral histone deacetylase inhibitor, in patients with advanced malignancies

被引：0

作者：

Ang, J. E. ^{[1
]}

Hauns, B. ^{[2
]}

Mais, A. ^{[2
]}

Parker, A. ^{[1
]}

Lal, R. ^{[1
]}

Olmos, D. ^{[1
]}

Mollenhauer, M. ^{[2
]}

Walz, A. ^{[2
]}

de Bono, J. S. ^{[1
]}

机构：

[1] Royal Marsden Hosp, Drug Dev Unit, Sutton, Surrey, England

[2] Nycomed GmbH, Exploratory Clin Dev, Constance, Germany

来源：

EJC SUPPLEMENTS | 2008年 / 6卷 / 12期

关键词：

D O I：

10.1016/S1359-6349(08)72327-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：123 / 124

页数：2

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[1] Phase I Study of the Oral Histone Deacetylase Inhibitor SB939 In Patients with Advanced Hematologic Malignancies [J].

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