Copper-free Sonogashira coupling in amine-water solvent mixtures

被引：54
作者：
Komaromi, Anna [1 ]
Tolnai, Gergely Laszlo [1 ]
Novak, Zoltan [1 ]
机构：
[1] Eotvos Lorand Univ, Inst Chem, Dept Organ Chem, Budapest, Hungary
来源：
TETRAHEDRON LETTERS | 2008年 / 49卷 / 51期
基金：
匈牙利科学研究基金会;
关键词：
Cross-coupling; Acetylenes; Sonogashira reaction; Palladium;
D O I：
10.1016/j.tetlet.2008.10.037
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Extensive study of different amine-water solvent mixtures was carried out for copper free Sonogashira coupling of aryl iodides. The influence of the palladium sources, ligands, amine-water ratio and further additives was also evaluated. Application of sec-butylamine-water mixture proved to be an excellent medium for rapid and efficient coupling of aryl-iodides at ambient temperature in the presence of PdCl2(PPh3)(2) as catalyst. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7294 / 7298
页数：5
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