Copper-free Sonogashira coupling in amine-water solvent mixtures

被引：54

作者：

Komaromi, Anna ^{[1
]}

Tolnai, Gergely Laszlo ^{[1
]}

Novak, Zoltan ^{[1
]}

机构：

[1] Eotvos Lorand Univ, Inst Chem, Dept Organ Chem, Budapest, Hungary

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 51期

基金：

匈牙利科学研究基金会;

关键词：

Cross-coupling; Acetylenes; Sonogashira reaction; Palladium;

D O I：

10.1016/j.tetlet.2008.10.037

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Extensive study of different amine-water solvent mixtures was carried out for copper free Sonogashira coupling of aryl iodides. The influence of the palladium sources, ligands, amine-water ratio and further additives was also evaluated. Application of sec-butylamine-water mixture proved to be an excellent medium for rapid and efficient coupling of aryl-iodides at ambient temperature in the presence of PdCl2(PPh3)(2) as catalyst. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：7294 / 7298

页数：5

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