Genetic and Epigenetic Studies for Determining Molecular Targets of Natural Product Anticancer Agents

被引：4

作者：

Wang, Yujiong ^{[1
,2
]}

Li, Yong ^{[1
,2
]}

Liu, Xiaoming ^{[1
,2
]}

Cho, William C. S. ^{[3
]}

机构：

[1] Ningxia Univ, Minist Educ Conservat & Utilizat Special Biol Res, Key Lab, Ningxia 750021, Peoples R China

[2] Ningxia Univ, Coll Life Sci, Ningxia 750021, Peoples R China

[3] Queen Elizabeth Hosp, Dept Clin Oncol, Hong Kong, Hong Kong, Peoples R China

来源：

CURRENT CANCER DRUG TARGETS | 2013年 / 13卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Cancer stem cells; epigenetics; genetics; microRNA; natural product; PROSTATE-CANCER CELLS; HISTONE DEACETYLASE INHIBITORS; GREEN TEA POLYPHENOL; MAMMARY EPITHELIAL-CELLS; SOY ISOFLAVONE GENISTEIN; TUMOR-SUPPRESSOR GENES; STEM-LIKE CELLS; FACTOR-KAPPA-B; BREAST-CANCER; MICRORNA EXPRESSION;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer is a disease caused by a series of genetic and epigenetic alterations. Therefore, agents targeting the genetic and/or epigenetic machinery offer potential for the development of anticancer drugs. Accumulating evidence has demonstrated that some common natural products [such as epigallocatechin-3-gallate (EGCG), curcumin, genistein, sulforaphane (SFN) and resveratrol] have anticancer properties through the mechanisms of altering epigenetic processes [including DNA methylation, histone modification, chromatin remodeling, microRNA (miRNA) regulation] and targeting cancer stem cells (CSCs). These bioactive compounds are able to revert epigenetic alterations in a variety of cancers in vitro and in vivo. They exert anticancer effects by targeting various signaling pathways related to the initiation, progression and metastasis of cancer. It appears that natural products hold great promise for cancer prevention and treatment by altering various epigenetic modifications. This review aims to discuss our current understanding of genetic and epigenetic targets of natural products and the effects of some common natural products on cancer chemoprevention and treatment.

引用

页码：506 / 518

页数：13

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