Targeting Anti-Cancer Active Compounds: Affinity-Based Chromatographic Assays

被引：21

作者：

de Moraes, Marcela Cristina ^{[1
]}

Cardoso, Carmen Lucia ^{[2
]}

Seidl, Claudia ^{[2
]}

Moaddel, Ruin ^{[3
]}

Cass, Quezia Bezerra ^{[4
]}

机构：

[1] Univ Fed Fluminense, Inst Quim, Dept Quim Organ, BR-24020141 Niteroi, RJ, Brazil

[2] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-14040901 Ribeirao Preto, SP, Brazil

[3] NIA, Lab Clin Invest, Div Intramural Res Programs, NIH, Baltimore, MD 21224 USA

[4] Univ Fed Sao Carlos, Dept Quim, Cx Postal 676, BR-13565905 Sao Carlos, SP, Brazil

来源：

CURRENT PHARMACEUTICAL DESIGN | 2016年 / 22卷 / 39期

基金：

巴西圣保罗研究基金会;

关键词：

Anti-cancer active compounds; screening method; affinity-based chromatography assays; PERFORMANCE LIQUID-CHROMATOGRAPHY; COATED MAGNETIC BEADS; PURINE NUCLEOSIDE PHOSPHORYLASE; CELL-MEMBRANE CHROMATOGRAPHY; STATIONARY-PHASE CHROMATOGRAPHY; SCREENING ANTITUMOR COMPONENTS; TRADITIONAL CHINESE MEDICINE; FACTOR RECEPTOR ANTAGONISTS; TYROSINE KINASE RECEPTOR; LIGAND-BINDING DOMAIN;

D O I：

10.2174/1381612822666160614080506

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Affinity-based chromatography assays encompass the use of solid supports containing immobilized biological targets to monitor binding events in the isolation, identification and/or characterization of bioactive compounds. This powerful bioanalytical technique allows the screening of potential binders through fast analyses that can be directly performed using isolated substances or complex matrices. An overview of the recent researches in frontal and zonal affinity-based chromatography screening assays, which has been used as a tool in the identification and characterization of new anti-cancer agents, is discussed. In addition, a critical evaluation of the recently emerged ligands fishing assays in complex mixtures is also discussed.

引用

页码：5976 / 5987

页数：12

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