KF/Al2O3 mediated aza-Michael addition of indoles to electron-deficient olefins

被引：5

作者：

Moghaddam, FM ^{[1
]}

Bardajee, GR ^{[1
]}

Taimoory, SMD ^{[1
]}

机构：

[1] Sharif Univ Technol, Dept Chem, Tehran, Iran

来源：

LETTERS IN ORGANIC CHEMISTRY | 2006年 / 3卷 / 02期

关键词：

KF/Al2O3; aza-Michael addition; N-alkylation; indole; electron-deficient olefins;

D O I：

10.2174/157017806775224224

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

KF/Al2O3 efficiently catalyzes aza-Michael addition of indole and 3-methylindole to a variety of electron-deficient conjugated alkenes such as alpha,beta-unsaturated ketones, amides and nitriles. The N-alkylation adducts are produced in good to excellent yields and relatively in short times. The catalyst can be recycled for subsequent reactions without any appreciable loss of efficiency.

引用

页码：157 / 160

页数：4