KF/Al2O3 mediated aza-Michael addition of indoles to electron-deficient olefins

被引：5
|
作者：
Moghaddam, FM [1 ]
Bardajee, GR [1 ]
Taimoory, SMD [1 ]
机构：
[1] Sharif Univ Technol, Dept Chem, Tehran, Iran
来源：
LETTERS IN ORGANIC CHEMISTRY | 2006年 / 3卷 / 02期
关键词：
KF/Al2O3; aza-Michael addition; N-alkylation; indole; electron-deficient olefins;
D O I：
10.2174/157017806775224224
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
KF/Al2O3 efficiently catalyzes aza-Michael addition of indole and 3-methylindole to a variety of electron-deficient conjugated alkenes such as alpha,beta-unsaturated ketones, amides and nitriles. The N-alkylation adducts are produced in good to excellent yields and relatively in short times. The catalyst can be recycled for subsequent reactions without any appreciable loss of efficiency.
引用
收藏
页码：157 / 160
页数：4
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