BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth

被引:1124
作者
Schneider, P
MacKay, F
Steiner, V
Hofmann, K
Bodmer, JL
Holler, N
Ambrose, C
Lawton, P
Bixler, S
Acha-Orbea, H
Valmori, D
Romero, P
Werner-Favre, C
Zubler, RH
Browning, JL
Tschopp, J
机构
[1] Univ Lausanne, Inst Biochem, CH-1066 Epalinges, Switzerland
[2] Swiss Inst Expt Canc Res, BIL Res Ctr, CH-1066 Epalinges, Switzerland
[3] CHU Vaudois, Ludwig Inst Canc Res, Dept Clin Oncoimmunol, CH-1011 Lausanne, Switzerland
[4] Univ Hosp Geneva, CMU, Div Haematol, CH-1211 Geneva 14, Switzerland
[5] Biogen Inc, Dept Immunol & Inflammat, Cambridge, MA 02142 USA
关键词
tumor necrosis factor; B lymphocytes; T lymphocytes; B cell growth; immunoglobulin G;
D O I
10.1084/jem.189.11.1747
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses, including cell growth, differentiation, and even death. Here we describe a novel member of the TNF family, designated BAFF (for B cell activating factor belonging to the TNF family), which is expressed by T cells and dendritic cells. Human BAFF was mapped to chromosome 13q32-34. Membrane-bound BAFF was processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein proprotein convertases. The expression of BAFF receptor appeared to be restricted to B cells. Both membrane-bound and soluble BAFF induced proliferation of anti-immunoglobulin M-stimulated peripheral blood B lymphocytes. Moreover, increased amounts of immunoglobulins were found in supernatants of germinal center-like B cells costimulated with BAFF. These results suggest that BAFF plays an important role as costimulator of B cell proliferation and function.
引用
收藏
页码:1747 / 1756
页数:10
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