Gold-Catalyzed Post-Ugi Cascade Transformation for the Synthesis of 2-Pyridones

被引：15

作者：

Du, Xiaochen ^{[1
]}

Yu, Jiafeng ^{[1
]}

Gong, Jing ^{[1
]}

Zaman, Manzoor ^{[1
]}

Pereshivko, Olga P. ^{[1
]}

Peshkov, Vsevolod A. ^{[1
,2
,3
]}

机构：

[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Dushu Lake Campus, Suzhou 215123, Peoples R China

[2] Nazarbayev Univ, Sch Sci & Technol, Dept Chem, 53 Kabanbay Batyr Ave,Block 7, Astana 010000, Kazakhstan

[3] Nazarbayev Univ, EREC, Astana, Kazakhstan

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 2019卷 / 14期

基金：

中国国家自然科学基金;

关键词：

Cascade transformations; Gold catalysis; Multicomponent reactions; 2-Pyridones; Ugi reaction; INTRAMOLECULAR HYDROARYLATION; ONE-POT; REGIOSELECTIVE SYNTHESIS; CONSTRUCTION; ALKYNES; CYCLOISOMERIZATIONS; PYRROLOPYRIDINONES; HETEROCYCLES; SELECTIVITY; ARENES;

D O I：

10.1002/ejoc.201900027

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A gold-catalyzed post-Ugi cascade transformation for the synthesis of 2-pyridones is described. The process involves furan-alkyne cyclization followed by furan ring-opening and cleavage of the isocyanide-originated fragment. The initially formed cis double bond can isomerize into a more stable trans double bond upon prolonged exposure to a strong Bronsted acid. Thus, the overall strategy provides a viable access towards two types of 2-pyridones.

引用

页码：2502 / 2507

页数：6

共 75 条

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