Nucleic acid enzymes

被引：45
作者：
Carola, C [1 ]
Eckstein, F [1 ]
机构：
[1] Max Planck Inst Expt Med, D-37075 Gottingen, Germany
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 1999年 / 3卷 / 03期
关键词：
D O I：
10.1016/S1367-5931(99)80043-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Last year provided new structural data, particularly for the group I intron and the Hepatitis delta ribozymes, that were essential for a better understanding of the RNA structure/function relationship. The role of metal ions in catalysis of ribozyme action still remains elusive, however. In vitro selection has continued to be a rich source for obtaining data on new nucleic acid enzyme activities.
引用
收藏
页码：274 / 283
页数：10
相关论文
共 78 条
[1]   Allosteric regulation of a ribozyme activity through ligand-induced conformational change [J].
Araki, M ;
Okuno, Y ;
Hara, Y ;
Sugiura, Y .
NUCLEIC ACIDS RESEARCH, 1998, 26 (14) :3379-3384
[2]   A specific monovalent metal ion integral to the AA platform of the RNA tetraloop receptor [J].
Basu, S ;
Rambo, RP ;
Strauss-Soukup, J ;
Cate, JH ;
Ferré-D'Amaré, AR ;
Strobel, SA ;
Doudna, JA .
NATURE STRUCTURAL BIOLOGY, 1998, 5 (11) :986-992
[3]   The parallel universe of RNA folding [J].
Batey, RT ;
Doudna, JA .
NATURE STRUCTURAL BIOLOGY, 1998, 5 (05) :337-340
[4]   Defining functional groups, core structural features and inter-domain tertiary contacts essential for group II intron self-splicing: a NAIM analysis [J].
Boudvillain, M ;
Pyle, AM .
EMBO JOURNAL, 1998, 17 (23) :7091-7104
[5]   Designing ribozymes for the inhibition of gene expression [J].
Bramlage, B ;
Luzi, E ;
Eckstein, F .
TRENDS IN BIOTECHNOLOGY, 1998, 16 (10) :434-438
[6]   Solution structure of loop a from the hairpin ribozyme from tobacco ringspot virus satellite [J].
Cai, ZP ;
Tinoco, I .
BIOCHEMISTRY, 1996, 35 (19) :6026-6036
[7]   Cleaving DNA with DNA [J].
Carmi, N ;
Balkhi, SR ;
Breaker, RR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (05) :2233-2237
[8]   RNAS WITH DUAL-SPECIFICITY AND DUAL RNAS WITH SIMILAR SPECIFICITY [J].
CONNELL, GJ ;
YARUS, M .
SCIENCE, 1994, 264 (5162) :1137-1141
[9]   Differential chemical probing of a group II self-splicing intron identifies bases involved in tertiary interactions and supports an alternative secondary structure model of domain V [J].
Costa, M ;
Christian, EL ;
Michel, F .
RNA, 1998, 4 (09) :1055-1068
[10]   Spectroscopic evidence for inner-sphere coordination of metal ions to the active site of a hammerhead ribozyme [J].
Cunningham, LA ;
Li, J ;
Lu, Y .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (18) :4518-4519
12345678