Bronsted acid promoted imino-ene reactions

被引：16

作者：

Oliver, Lindsey H. ^{[1
]}

Puls, Lauren A. ^{[1
]}

Tobey, Suzanne L. ^{[1
]}

机构：

[1] Wake Forest Univ, Dept Chem, Winston Salem, NC 27109 USA

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 31期

关键词：

organocatalysis; ene reaction; phosphonic acid; hydrogen bonding;

D O I：

10.1016/j.tetlet.2008.05.075

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of all-carbon olefins react with glyoxylate derived imines in the presence of a phosphonic acid through an ene reaction. The isolation of the ot-amincester products is a clear indication that Bronsted acids efficiently promote the imino-ene reaction with hydrocarbon nucleophiles to deliver functionalized ot-aminoesters in good yield. The reaction scope and preliminary mechanistic investigations are discussed. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：4636 / 4639

页数：4

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