Phosphonium lipocations as antiparasitic agents

被引：24

作者：

Long, Timothy E. ^{[1
,2
]}

Lu, Xiao ^{[1
,2
]}

Galizzi, Melina ^{[3
,4
]}

Docampo, Roberto ^{[3
,4
]}

Gut, Jiri ^{[5
]}

Rosenthal, Philip J. ^{[5
]}

机构：

[1] Univ Georgia, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA

[2] Univ Georgia, Ctr Drug Discovery, Athens, GA 30602 USA

[3] Univ Georgia, Ctr Trop & Emerging Global Dis, Athens, GA 30602 USA

[4] Univ Georgia, Dept Cellular Biol, Athens, GA 30602 USA

[5] Univ Calif San Francisco, Dept Med, San Francisco Gen Hosp, San Francisco, CA 94143 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 08期

基金：

美国国家卫生研究院;

关键词：

Malaria; Chagas; Antiparasitic drugs; Plasmodium; Trypanosoma; VISIBLE LIPIDS; MITOCHONDRIA; SALTS; CATIONS; DRUGS; CHEMOTHERAPY; ANTIOXIDANT; ARTEMISININ; INHIBITION; ACTIVATION;

D O I：

10.1016/j.bmcl.2012.02.045

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Phosphonium lipocations were synthesized and evaluated for inhibition of the development of Plasmodium falciparum and Trypanosoma cruzi, etiological agents of malaria and Chagas disease, respectively. Optimal phthalimides and 1,4-naphthoquinone-based lipocations were active in vitro at mid-high nM concentrations against P. falciparum and low mu M concentrations against T. cruzi. Published by Elsevier Ltd.

引用

页码：2976 / 2979

页数：4

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